IL1RN

Gene Symbol IL1RN
Entrez Gene 3557
Alt Symbol DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4
Species Human
Gene Type protein-coding
Description interleukin 1 receptor antagonist
Other Description IL1 inhibitor|IL1RN (IL1F3)|interleukin-1 receptor antagonist protein|intracellular IL-1 receptor antagonist type II|intracellular interleukin-1 receptor antagonist (icIL-1ra)|type II interleukin-1 receptor antagonist
Swissprots Q53SC2 Q14628 P18510 Q9UPC0 Q96GD6 Q7RTZ4 A8K4G1
Accessions AAB41943 AAB92268 AAB92269 AAB92270 AAC13499 AAN87150 AAX93278 CAA03191 CAA03210 CAA45832 CAD29879 CAJ91094 CBY45189 EAW73621 EAW73622 EAW73623 EAW73624 EAW73625 P18510 AF043143 AAC39672 AJ005835 CAA06730 AK290898 BAF83587 AK290926 BAF83615 BC009745 AAH09745 BC068441 BI766516 DQ892566 ABM83492 DQ895781 ABM86707 M55646 AAA59138 X52015 CAA36262 X53296 CAA37386 X84348 CAA59087 XM_005263661 XP_005263718 XM_006712497 XP_006712560 XM_011511121 XP_011509423 NM_000577 NP_000568 NM_173841 NP_776213 NM_173842 NP_776214 NM_173843 NP_776215
Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. {ECO:0000269|PubMed:7775431}.
Subcellular Location Isoform 3: Cytoplasm.
Tissue Specificity The intracellular form of IL1RN is predominantly expressed in epithelial cells.

IL-1RA (20D8) Mouse mAb - 3865 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 20D8
Western blot analysis of variable amounts of recombinant human IL-1RA protein and A431 cell lysate using IL-1RA (20D8) Mouse mAb.

IL-1ra (A-4) - sc-374084 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-1ra (A-4): sc-374084. Western blot analysis of IL-1ra expression in A-431 whole cell lysate.

IL-1ra (5G11) - sc-101342 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

IL-1ra (6A8) - sc-101616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-1ra (6A8): sc-101616. Western blot analysis of IL-1ra expression in human PBL whole cell lysate.

IL-1ra (C-20) - sc-8480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-1ra (C-20): sc-8480. Western blot analysis of human recombinant IL-1ra fusion protein.

IL-1ra (H-110) - sc-25444 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-1ra (H-110): sc-25444. Western blot analysis of human recombinant IL-1ra fusion protein.

IL-1ra (N-19) - sc-8479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-1ra (N-19): sc-8479. Western blot analysis of human recombinant IL-1ra fusion protein.

IL-1ra (AS17) - sc-52775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

IL-1ra (A-11) - sc-376094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-1ra (A-11): sc-376094. Western blot analysis of IL-1ra expression in A-431 whole cell lysate.

Anti-IL-1ra/IL-1F3 antibody [5C5] - ab180536 from Abcam

Prices $357.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C5
All lanes : Anti-IL-1ra/IL-1F3 antibody [5C5] (ab180536) at 1/2000 dilutionLane 1 : Lysate from HEK293T cells transfected with pCMV6-ENTRY control cDNA for 48 hrsLane 2 : Lysate from HEK293T cells transfected with pCMV6-ENTRY IL-1ra/IL-1F3 cDNA for 48 hrsLysates/proteins at 5 µg per lane.developed using the ECL technique

Anti-IL1RA antibody - ab2573 from Abcam

Prices $397.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab2573 stained MCF-7 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab2573, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-IL1RA antibody - ab175392 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat pancreas tissue labelling IL1RA with ab175392 at 1/200. Magnification: 400x.

Anti-IL1RA antibody - ab135570 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL1RA antibody (ab135570) at 1/50 dilutionLane 1 : Non transfected 293 cell lysate Lane 2 : 293 cell lysate transiently transfected with the IL1RA geneLysates/proteins at 2 µg per lane.

Anti-IL1RA antibody - ab97301 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-IL1RA antibody (ab97301) at 1/1000 dilution + Molt-4 whole cell lysate at 30 µg

Anti-IL1RA antibody - ab104876 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IL1RA antibody (ab104876) at 1 µg/ml + A431 (Human epithelial carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL1RA antibody - ab123235 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL1RA antibody (ab123235) at 1 µg/ml + 293T cell lysate at 10 µgSecondaryGoat anti-Rabbit IgG HRP

Anti-IL1RA antibody - ab60978 from Abcam

Host Sheep
Clonality Polyclonal
Anti-IL1RA antibody (ab60978) at 5 µg/ml + Recombinant human IL-1Ra. at 0.1 µgSecondaryanti-sheep IgG - HRP at 1/10000 dilution

Anti-IL1RA antibody [A71B6D11] (Biotin) - ab25074 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A71B6D11

Anti-IL1RA antibody [AS17], prediluted (FITC) - ab28315 from Abcam

Prices $376.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone AS17
Overlay histogram showing peripheral blood lymphocytes cells stained with ab28315 (red line). The cells were fixed with 4% paraformaldehydel (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab28315, 0.25µg/1x106 cells) for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 (0.25µg/1x106 cells ). Acquisition of >5,000 events was performed.

Anti-IL1RA antibody [EPR6483] - ab124962 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6483
Overlay histogram showing A431 cells stained with ab124962 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab124962, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-IL1RA antibody [MM0389-2V23] - ab90934 from Abcam

Prices $370.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone MM0389-2V23

Anti-IL1RN Antibody (aa1-177) - LS-C185816 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded PC3 xenograft using IL1 Receptor antagonist antibody at 1:500 dilution.

Anti-IL1RN Antibody - LS-C335202 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat pancreas using IL1RN antibody at dilution of 1:200 (400x lens).

Anti-IL1RN Antibody (clone 2B1) - LS-C338743 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B1
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-IL1RN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-IL1RN Antibody - LS-C24848 from LifeSpan Bioscience

Prices $515.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Search more