CBX5

Gene Symbol CBX5
Entrez Gene 23468
Alt Symbol HEL25, HP1, HP1A
Species Human
Gene Type protein-coding
Description chromobox homolog 5
Other Description HP1 alpha homolog|HP1-ALPHA|HP1Hs alpha|antigen p25|chromobox homolog 5 (HP1 alpha homolog, Drosophila)|chromobox protein homolog 5|epididymis luminal protein 25|heterochromatin protein 1 homolog alpha|heterochromatin protein 1-alpha
Swissprots B2R8T9 P45973
Accessions EAW96758 EAW96759 EAW96760 P45973 AF147443 AK023520 AK055641 AK056315 AK095108 AK313506 BAG36286 BC006821 AAH06821 BC030149 BC047432 BP236173 BP336150 CR457418 CAG33699 DT217255 EU446624 ABZ92153 EU446784 ABZ92313 EU794599 ACJ13653 L07515 AAA72327 S62077 AAB26994 U26311 AAC50553 NM_001127321 NP_001120793 NM_001127322 NP_001120794 NM_012117 NP_036249
Function Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. {ECO:0000269|PubMed:19783980}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10460410}. Chromosome {ECO:0000269|PubMed:10460410}. Chromosome, centromere {ECO:0000269|PubMed:10460410}. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.

CBX5-Over-expression-Lysate - LY14353a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CBX5 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CBX5 gene.

CBX5 293T Cell Transient Overexpression Lysate(Denatured) - H00023468-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

CBX5 293 Cell Lysate - 401900 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Species Drosophila

HP1 alpha Overexpression Lysate (Native) - NBL1-08750 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: HP1 alpha Overexpression Lysate (Adult Normal) [NBL1-08750] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HP1 alpha.

HP1α (h): 293 Lysate - sc-110608 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

CBX5 Over-expression Lysate Product - GWB-9B6BA7 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

HP1 alpha Overexpression Lysate (Native) - NBP2-11379 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: HP1 alpha Overexpression Lysate (Adult Normal) [NBP2-11379] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HP1 alpha.

HP1 alpha Overexpression Lysate (Native) - NBP2-11378 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: HP1 alpha Overexpression Lysate (Adult Normal) [NBP2-11378] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HP1 alpha.

HP1 alpha Overexpression Lysate (Denatured) - H00023468-T01 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human CBX5 Knockdown Stable Cell Line - CSC-DC002440 from Creative biogene

Category Cell Line
Species Human

Human CBX5 Knockout Cell Line-HeLa - CSC-RT1579 from Creative biogene

Category Cell Line
Species Human

CBX5 KO Cell Lysate-HeLa - CLKO-1426 from Creative biogene

Category Cell Lysate
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