CBX5

Gene Symbol	CBX5
Entrez Gene	23468
Alt Symbol	HEL25, HP1, HP1A
Species	Human
Gene Type	protein-coding
Description	chromobox homolog 5
Other Description	HP1 alpha homolog|HP1-ALPHA|HP1Hs alpha|antigen p25|chromobox homolog 5 (HP1 alpha homolog, Drosophila)|chromobox protein homolog 5|epididymis luminal protein 25|heterochromatin protein 1 homolog alpha|heterochromatin protein 1-alpha
Swissprots	B2R8T9 P45973
Accessions	EAW96758 EAW96759 EAW96760 P45973 AF147443 AK023520 AK055641 AK056315 AK095108 AK313506 BAG36286 BC006821 AAH06821 BC030149 BC047432 BP236173 BP336150 CR457418 CAG33699 DT217255 EU446624 ABZ92153 EU446784 ABZ92313 EU794599 ACJ13653 L07515 AAA72327 S62077 AAB26994 U26311 AAC50553 NM_001127321 NP_001120793 NM_001127322 NP_001120794 NM_012117 NP_036249
Function	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. {ECO:0000269|PubMed:19783980}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10460410}. Chromosome {ECO:0000269|PubMed:10460410}. Chromosome, centromere {ECO:0000269|PubMed:10460410}. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HP1 alpha peptide - ab4718 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Source CHO

Human HP1 alpha full length protein - ab124602 from Abcam Category Protein Source E. coli Species Human

CBX5 / HP1 Alpha Antibody Blocking Peptide - LS-E2700 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBX5 / HP1 Alpha Antibody Blocking Peptide - LS-E6474 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBX5 / HP1 Alpha Antibody Blocking Peptide - LS-E11388 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBX5 / HP1 Alpha Antibody Blocking Peptide - LS-E25964 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HP1 alpha Recombinant Protein - H00023468-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HP1 alpha Protein - NBP1-98863 from Novus Biologicals Category Protein Prices $309.00 Sizes 100 µg Species Human

CBX5-Antibody-Center-Blocking-peptide - BP13779c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HP1 alpha blocking peptide - GTX89432-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog

Human CBX5 protein - orb168047 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E.coli Species Human

CBX5 Immunizing peptide - orb17597 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

CBX5 protein (His tag) - 80R-2204 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

TFF1 protein - 30R-2751 from Fitzgerald Category Protein Prices $265.00 Sizes 20 µg Source E.coli Species Human

HP1 alpha Peptide - AC21-0791-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CBX5 (1-191, His-tag) - AR50286PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CBX5 (1-191, His-tag) - AR50286PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CBX5 - H00023468-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CBX5 - H00023468-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CBX5, 1-191aa, Human, His tag, E.coli - 01-P1461 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CBX5 Peptide - 45-372P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

CBX5 fusion protein - ag2403 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Chromobox Homolog 5 Protein - BP001889-PRO-1062 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human CBX5, His-tagged - CBX5-27763TH from Creative Biomart Category Protein Source E. coli

HP1 alpha Blocking Peptide - CBP2578 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

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