PDPN

Gene Symbol PDPN
Entrez Gene 10630
Alt Symbol AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A
Species Human
Gene Type protein-coding
Description podoplanin
Other Description PA2.26 antigen|T1-alpha|glycoprotein 36|glycoprotein, 36-KD|hT1alpha-1|hT1alpha-2|lung type I cell membrane associated glycoprotein|lung type-I cell membrane-associated glycoprotein (T1A-2)
Swissprots Q8NBQ8 O95128 E9PB68 A9Z1Y2 F6QWX5 Q86YL7 Q7L375 Q8NBR3 O60836 B2R6J8
Accessions EAW51691 EAW51692 EAW51693 EAW51694 Q86YL7 AB127958 BAD04046 AF030427 AAD01899 AF030428 AAD01900 AF390106 AAM73655 AJ225022 CAA12352 AK075327 BAC11550 AK075345 BAC11557 AK307705 AK307706 AK312607 BAG35495 AW022996 AY194238 AAO22143 BC014668 AAH14668 BC022812 AAH22812 BE887331 BF340649 BQ212176 BQ214601 CA312590 CD245679 XM_006710295 XP_006710358 NM_001006624 NP_001006625 NM_001006625 NP_001006626 NM_006474 NP_006465 NM_198389 NP_938203
Function May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. {ECO:0000250|UniProtKB:Q62011, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15231832, ECO:0000269|PubMed:15515019, ECO:0000269|PubMed:9651190}.
Subcellular Location Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, filopodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. {ECO:0000250}.
Tissue Specificity Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. {ECO:0000269|PubMed:10393083, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15515019}.

HIV2 gp36 peptide - ab43147 from Abcam

Category Peptide
Prices $290.00
Sizes 500 µg

HIV2 gp36 protein fragment - ab73034 from Abcam

Category Protein
Prices $747.00
Sizes 1 mg
Source Pichia pastoris
HIV-2 gp36 ELISA with HIV-2 positive sera at 1:2,000 with 1-100 nanograms per well gp36. Background with BSA or normal sera OD405 <0.1. Alkaline phosphatase substrate for 45 min.

HIV2 gp36 protein fragment - ab43035 from Abcam

Category Protein
Prices $192.00
Sizes 200 µg
Source E. coli

HIV2 gp36 protein fragment - ab49057 from Abcam

Category Protein
Prices $192.00
Sizes 100 µg
Source E. coli

Human Podoplanin / gp36 full length protein - ab132033 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE stained with Coomassie Blue showing ab132033 at approximately 51.3 kDa.

Human Podoplanin / gp36 protein fragment - ab152053 from Abcam

Category Protein
Source HEK 293 cells
Species Human

Human Podoplanin / gp36 protein fragment - ab87357 from Abcam

Category Protein
Source E. coli
Species Human
15% SDS-PAGE showing ab87357 (3µg). Note: Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.

Human Podoplanin / gp36 protein fragment - ab117687 from Abcam

Category Protein
Source E. coli
Species Human

Mouse Podoplanin / gp36 protein fragment - ab129032 from Abcam

Category Protein
Source E. coli
Species Mouse
SDS-PAGE analysis of ab129032. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Silver stain.

PDPN / Podoplanin Antibody Blocking Peptide - LS-E16362 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PDPN / Podoplanin Antibody Blocking Peptide - LS-E6807 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PDPN / Podoplanin Antibody Blocking Peptide - LS-E27096 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Podoplanin Protein - NBC1-18511 from Novus Biologicals

Category Protein
Prices $269.00
Sizes 100 µg
Source E.coli
Species Human
SDS-Page: Podoplanin Protein [NBC1-18511] - PDPN, 13.4 kDa (130 aa), confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE

Podoplanin Recombinant Protein - H00010630-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Podoplanin Peptide - P0808 from Novus Biologicals

Category Peptide
Species Human

gp38 - SP3077b from Abgent, a WuXi AppTec company

Category Peptide
Prices $185.00
Sizes 1 mg

gp38 - SP3077a from Abgent, a WuXi AppTec company

Category Peptide
Prices $125.00
Sizes 500 µg

Podoplanin--GP36--T1A-2-Antibody-N-term-Blocking-peptide - BP2016b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Podoplanin blocking peptide - GTX88363-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Dog

Recombinant Human Podoplanin Fc Chimera, CF - 3670-PL-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived

HIV-2 env.gp36 Protein (OPMA04702) - OPMA04702 from Aviva Systems Biology

Category Protein
Prices $845.00
Sizes 1 mg
Source E. coli

HIV-2 Ag gp36 Protein (OPMA04734) - OPMA04734 from Aviva Systems Biology

Category Protein
Prices $640.00
Sizes 100 µg
Source E. coli

PDPN Protein (OPPA01756) - OPPA01756 from Aviva Systems Biology

Category Protein
Prices $100.00
Sizes 5 µg

Human AGGRUS protein - orb83541 from Biorbyt

Category Protein
Prices $400.00, $612.00
Sizes 50 μg, 100 μg
Source Human
Species Human
SDS-PAGE analysis of Human Podoplanin Fc His tag protein

Human PDPN protein - orb49595 from Biorbyt

Category Protein
Prices $255.00, $349.00, $1,904.00, $2,695.00
Sizes 10 μg, 50 μg, 500 μg, 1 mg
Species Human
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