| Gene Symbol |
PDPN
|
| Entrez Gene |
10630
|
| Alt Symbol |
AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
podoplanin
|
| Other Description |
PA2.26 antigen|T1-alpha|glycoprotein 36|glycoprotein, 36-KD|hT1alpha-1|hT1alpha-2|lung type I cell membrane associated glycoprotein|lung type-I cell membrane-associated glycoprotein (T1A-2)
|
| Swissprots |
Q8NBQ8 O95128 E9PB68 A9Z1Y2 F6QWX5 Q86YL7 Q7L375 Q8NBR3 O60836 B2R6J8
|
| Accessions |
EAW51691 EAW51692 EAW51693 EAW51694 Q86YL7 AB127958 BAD04046 AF030427 AAD01899 AF030428 AAD01900 AF390106 AAM73655 AJ225022 CAA12352 AK075327 BAC11550 AK075345 BAC11557 AK307705 AK307706 AK312607 BAG35495 AW022996 AY194238 AAO22143 BC014668 AAH14668 BC022812 AAH22812 BE887331 BF340649 BQ212176 BQ214601 CA312590 CD245679 XM_006710295 XP_006710358 NM_001006624 NP_001006625 NM_001006625 NP_001006626 NM_006474 NP_006465 NM_198389 NP_938203
|
| Function |
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. {ECO:0000250|UniProtKB:Q62011, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15231832, ECO:0000269|PubMed:15515019, ECO:0000269|PubMed:9651190}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, filopodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. {ECO:0000269|PubMed:10393083, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15515019}.
|