| Gene Symbol |
STAM
|
| Entrez Gene |
8027
|
| Alt Symbol |
STAM-1, STAM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
|
| Other Description |
HSE1 homolog|signal transducing adapter molecule 1
|
| Swissprots |
Q92783 Q8N6D9 D3DRU5 B0YJ99
|
| Accessions |
ACA06077 ACA06078 CAY55994 EAW86207 EAW86208 EAW86209 Q92783 AK024383 AK303083 BAG64194 AK314405 BAG37028 AU118708 BC030586 AAH30586 BX647982 U43899 AAC50734 XM_005252603 XP_005252660 XM_011519695 XP_011517997 NM_003473 NP_003464 NR_037774
|
| Function |
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:8780729}.
|
| Top Pathways |
Jak-STAT signaling pathway, Endocytosis
|