STAM

Gene Symbol	STAM
Entrez Gene	8027
Alt Symbol	STAM-1, STAM1
Species	Human
Gene Type	protein-coding
Description	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Other Description	HSE1 homolog|signal transducing adapter molecule 1
Swissprots	Q92783 Q8N6D9 D3DRU5 B0YJ99
Accessions	ACA06077 ACA06078 CAY55994 EAW86207 EAW86208 EAW86209 Q92783 AK024383 AK303083 BAG64194 AK314405 BAG37028 AU118708 BC030586 AAH30586 BX647982 U43899 AAC50734 XM_005252603 XP_005252660 XM_011519695 XP_011517997 NM_003473 NP_003464 NR_037774
Function	Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Subcellular Location	Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:8780729}.
Top Pathways	Jak-STAT signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human STAM1 full length protein - ab188708 from Abcam Category Protein Prices $342.00 Sizes 50 µg Source E. coli Species Human

Human STAM1 full length protein - ab159929 from Abcam Category Protein Source Wheat germ Species Human

STAM1 / STAM Antibody Blocking Peptide - LS-E23020 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAM1 / STAM Antibody Blocking Peptide - LS-E6923 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAM-1 Recombinant Protein - H00008027-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

STAM-1 Peptide - P1008 from Novus Biologicals Category Peptide Species Human

STAM-1 Peptide - P1007 from Novus Biologicals Category Peptide Species Human

STAM-Antibody-C-term-Blocking-Peptide - BP2180b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STAM-Antibody-N-term-Blocking-Peptide - BP2180a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human STAM-1, CF - E-550-050 from R&D Systems Category Protein Source E. coli-derived,

STAM1 - H00008027-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

STAM1 - H00008027-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

STAM fusion protein - Ag3112 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human STAM, GST-tagged - STAM-2988H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Signal Transducing Adaptor Molecule 1 (STAM1) - RPB588Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Signal Transducing Adaptor Molecule 1 (STAM1) - RPB588Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Signal Transducing Adaptor Molecule 1 (STAM1) - RPB588Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Human Signal transducing adapter molecule 1(STAM) - CSB-YP846097HU CSB-EP846097HU CSB-BP846097HU CSB-MP846097HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human STAM-1 Protein, CF - E-550 from R&D Systems Category Protein Prices $165.00 Sizes 50 µg Source E. coli -derived Species Human

STAM-1 - E-550 from Boston Biochem Prices $165.00 Sizes 50 µg

STAM1 - TP319230 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human Signal transducing adapter molecule 1/STAM, transfected HEK293 cell lysate - 230-10174-100 from RayBiotech Category Protein Prices $135.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Recombinant Human Signal transducing adapter molecule 1/STAM, transfected HEK293 cell culture supernatant - 230-20141-200 from RayBiotech Category Protein Prices $110.00 Sizes 200 µl Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

STAM-1 Protein - NBP2-38514PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

STAM Peptide, Human - M34GP15264H from Creative Peptides Category Peptide Source Synthetic. Species Human

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