| Gene Symbol |
NEXN
|
| Entrez Gene |
91624
|
| Alt Symbol |
CMH20, NELIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nexilin (F actin binding protein)
|
| Other Description |
nexilin
|
| Swissprots |
Q9Y2V1 B4DPZ7 Q14CC3 Q16081 A0PJ84 Q0D2H2 Q96DL0 Q14CC2 Q7Z2X0 Q0ZGT2
|
| Accessions |
EAX06359 EAX06360 EAX06361 EAX06362 Q0ZGT2 AA249326 AF114264 AAD29607 AF176780 AAQ13658 AK057954 BAB71622 AK127535 AK293201 BAG56741 AK298565 BAG60759 AK300728 BAG62401 AK307487 AY211912 AAO65165 BC017827 AAH17827 BC055084 AAH55084 BC111395 AAI11396 BC114444 AAI14445 BC114445 AAI14446 BQ009808 BX648546 CR936630 CAI56773 DC412178 DQ464902 ABE97925 S67069 AAB28815 XM_005271322 XP_005271379 XM_005271323 XP_005271380 XM_005271324 XP_005271381 XM_005271325 XP_005271382 XM_005271326 XP_005271383 XM_005271327 XP_005271384 NM_001172309 NP_001165780 NM_144573 NP_653174
|
| Function |
Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z2J4}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ (By similarity). {ECO:0000250|UniProtKB:Q9Z2J4, ECO:0000269|PubMed:15823560}.
|
| Tissue Specificity |
Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLaS3 and MOLT-4 cell lines. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}.
|