NEXN

Gene Symbol NEXN
Entrez Gene 91624
Alt Symbol CMH20, NELIN
Species Human
Gene Type protein-coding
Description nexilin (F actin binding protein)
Other Description nexilin
Swissprots Q9Y2V1 B4DPZ7 Q14CC3 Q16081 A0PJ84 Q0D2H2 Q96DL0 Q14CC2 Q7Z2X0 Q0ZGT2
Accessions EAX06359 EAX06360 EAX06361 EAX06362 Q0ZGT2 AA249326 AF114264 AAD29607 AF176780 AAQ13658 AK057954 BAB71622 AK127535 AK293201 BAG56741 AK298565 BAG60759 AK300728 BAG62401 AK307487 AY211912 AAO65165 BC017827 AAH17827 BC055084 AAH55084 BC111395 AAI11396 BC114444 AAI14445 BC114445 AAI14446 BQ009808 BX648546 CR936630 CAI56773 DC412178 DQ464902 ABE97925 S67069 AAB28815 XM_005271322 XP_005271379 XM_005271323 XP_005271380 XM_005271324 XP_005271381 XM_005271325 XP_005271382 XM_005271326 XP_005271383 XM_005271327 XP_005271384 NM_001172309 NP_001165780 NM_144573 NP_653174
Function Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z2J4}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ (By similarity). {ECO:0000250|UniProtKB:Q9Z2J4, ECO:0000269|PubMed:15823560}.
Tissue Specificity Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLaS3 and MOLT-4 cell lines. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}.

Anti-Nexilin antibody - ab83746 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Nexilin antibody (ab83746) at 1 µg/ml (in 5% skim milk/ PBS) + Fetal liver lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Nexilin antibody - ab140435 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Nexilin in Immunoprecipitates of Jurkat whole cell lysates (1 mg for IP, 20% of IP loaded) using ab118807 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-Nexilin antibody which recognizes a downstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-NEXN / Nexilin Antibody (aa214-455, FITC) - LS-C303240 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NEXN / Nexilin Antibody (aa214-455, Biotin) - LS-C301067 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NEXN / Nexilin Antibody (aa200-250) - LS-C290456 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Nexillin by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-Nexillin antibody used for IP at 6 ug/mg lysate. Nexillin was also immunoprecipitated by rabbit anti-Nexillin antibody BL13584, which recognizes a downstream epitope. For blotting immunoprecipitated Nexillin, rabbit anti-Nexillin antibody BL13585 was used at 1 mcg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-NEXN / Nexilin Antibody (aa252-301) - LS-C102280 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NEXN antibody LS-C102280 Western blot of Fetal Liver lysate.

Anti-NEXN / Nexilin Antibody (aa214-455) - LS-C295624 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant NEXN / Nexilin.

Nexilin Antibody - NBP1-53226 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nexilin Antibody - NBP1-92179 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Nexilin Antibody [NBP1-92179] - Staining of human cerebellum shows moderate cytoplasmic positivity in purkinje cells.

Nexilin Antibody - 47120002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: Nexilin Antibody [47120002]

Monoclonal Anti-Nexilin antibody produced in mouse - SAB4200124 from Sigma-Aldrich

Prices $55.60, $322.00
Sizes 25 µl, 200 µl
Host Mouse
Clonality Monoclonal
Clone NX-38
<B>Immunoblotting</B><BR/>Rat brain extract was separated on SDS-PAGE and probed with Mouse Anti-Nexillin Clone: NX-38 (<B>Cat. No. SAB4200124</B>). The antibody was developed using Goat Anti-Mouse IgG-Peroxidase (<B>Cat. No. A2304</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. 2 μg/mL antibody<BR/>2. 2 μg/mL antibody + Nexillin immunizing peptide

Anti-NEXN antibody produced in rabbit - SAB2101574 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NEXN: <B>Cat. No.SAB2101574</B>: NEXN in Fetal Liver tissue lysate with NEXN antibody at 1.0 μg/mL.

Anti-NEXN antibody produced in rabbit - HPA011185 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NEXN: <B>Cat. No. HPA011185</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebellum shows moderate cytoplasmic positivity in purkinje cells.

NEXN antibody - middle region (ARP48028_P050) - ARP48028_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NEXN antibody, Internal - GTX46266 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

Nexilin antibody - 70R-2949 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

NEXN Antibody - 26-273 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

NEXN Antibody - GWB-MQ982A from Genway Biotech

Prices $404.00
Sizes 50 µg
Clonality Polyclonal

Anti-NEXN (aa 200-250) polyclonal antibody - DPABH-02307 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-NEXN (aa 252-301) polyclonal antibody - DPABH-18424 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Nexilin Antibody - A303-806A from Bethyl Labs

Prices $99.00, $339.00
Sizes 10 µl (1 mg/ml), 100 µl (1 mg/ml)
Host Rabbit
Clonality Polyclonal

Monoclonal Antibody to Nexilin (NEXN) - MAH548Hu21 from Uscn Life Science Inc.

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Nexilin (NEXN) - PAH548Hu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Nexilin (NEXN) - PAH548Mu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Nexilin (NEXN) - PAH548Ra01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal
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