SIRPA

Gene Symbol	SIRPA
Entrez Gene	140885
Alt Symbol	BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
Species	Human
Gene Type	protein-coding
Description	signal-regulatory protein alpha
Other Description	CD172 antigen-like family member A|brain-immunoglobulin-like molecule with tyrosine-based activation motifs|inhibitory receptor SHPS-1|macrophage fusion receptor|myd-1 antigen|tyrosine phosphatase SHP substrate 1|tyrosine-protein phosphatase non-receptor type substrate 1
Swissprots	Q9Y4U9 O43799 A8K411 Q9H0Z2 Q8N517 Q8TAL8 O00683 Q9UDX2 A2A2E1 P78324 B2R6C3 Q9UIJ6
Accessions	EAX10606 EAX10607 EAX10608 EAX10609 EAX10610 EAX10611 P78324 AB023430 BAA87929 AK290776 BAF83465 AK298243 BAG60509 AK312521 BAG35420 BC026692 AAH26692 BC033092 AAH33092 BC038510 AAH38510 BC075849 AAH75849 D86043 BAA12974 DA471662 DN989886 DQ891651 ABM82577 U06681 U06701 Y10375 CAA71403 Y11047 CAA71944 XM_005260669 XP_005260726 XM_005260670 XP_005260727 XM_006723545 XP_006723608 XM_006723546 XP_006723609 XM_006723547 XP_006723610 XM_011529172 XP_011527474 XM_011529173 XP_011527475 NM_001040022 NP_001035111 NM_001040023 NP_001035112 NM_080792 NP_542970
Function	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. {ECO:0000250, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat SIRPA / CD172a ELISA Kit (Cell-Based ELISA) - LS-F2308 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human SIRPA / CD172a ELISA Kit (Sandwich ELISA) - LS-F9198 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.156-10 ng/ml

Signal Regulatory Protein Alpha (SIRPa), Human, ELISA Kit - SEA953Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.061ng/mL Range 0.156-10ng/mL

Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), Human, ELISA Kit - CSB-EL021334HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Signal Regulatory Protein Alpha (SIRPa), ELISA Kit - MBS2019546 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.054ng/mL. Range 0.156-10ng/mL.

SIRPA - MBS2515696 from MyBioSource Category ELISA Kit Prices $430.00, $520.00 Sizes 48 strip wells, 96 strip wells Sensitivity The minimum detectable dose of Human SIRPA is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

Sirp alpha1 Colorimetric Cell-Based ELISA Kit - CB5632 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human SIRPA(Signal Regulatory Protein Alpha) ELISA Kit - E-EL-H1573 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

signal-regulatory protein alpha, ELISA Kit - MBS939286 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) - SEA953Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.056ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA) ELISA kit - CSB-EL021334HU from Cusabio Category ELISA Kit Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) - SEA953Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.056ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Pro-MMP-13(Pro-Matrix Metalloproteinase 13) ELISA Kit - E-EL-H1573 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human SIRPa ELISA Kit - abx153089 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human SIRPA / CD172a ELISA Kit (Sandwich ELISA) - LS-F21136 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.157 ng/ml Range 0.156-10 ng/ml

Signal Regulatory Protein Alpha (SIRPa), Human, ELISA Kit - DL-SIRPa-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Signal Regulatory Protein Alpha, SIRPA, Human, ELISA Kit - E-EL-H1573 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Human SIRPa ELISA Kit - abx571701 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

SIRPa - EKH7568 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156--10ng/ml

Custom Human SIRP alpha ELISA - ELH-SIRPa-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human SIRPA ELISA Kit - E035245 from Biobool Category ELISA Kit Sensitivity Typically less than 0.056ng/mL.

SIRPA ELISA Kit (Human) (OKCD01554) - OKCD01554 from Aviva Systems Biology Category ELISA Kit Prices $505.00 Sizes 96 wells Sensitivity < 0.056 ng/mL Range 0.156 - 10 ng/mL

anti-CD172a antibody [BL1H7] - ARG22750 from Arigo Biolaboratories Category ELISA Kit

Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) ELISA Kit - AE19488HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.056 ng/mL Range 0.156-10 ng/mL

Signal Regulatory Protein Alpha, ELISA Kit - MBS762476 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

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