SIRPA

Gene Symbol	SIRPA
Entrez Gene	140885
Alt Symbol	BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
Species	Human
Gene Type	protein-coding
Description	signal-regulatory protein alpha
Other Description	CD172 antigen-like family member A|brain-immunoglobulin-like molecule with tyrosine-based activation motifs|inhibitory receptor SHPS-1|macrophage fusion receptor|myd-1 antigen|tyrosine phosphatase SHP substrate 1|tyrosine-protein phosphatase non-receptor type substrate 1
Swissprots	Q9Y4U9 O43799 A8K411 Q9H0Z2 Q8N517 Q8TAL8 O00683 Q9UDX2 A2A2E1 P78324 B2R6C3 Q9UIJ6
Accessions	EAX10606 EAX10607 EAX10608 EAX10609 EAX10610 EAX10611 P78324 AB023430 BAA87929 AK290776 BAF83465 AK298243 BAG60509 AK312521 BAG35420 BC026692 AAH26692 BC033092 AAH33092 BC038510 AAH38510 BC075849 AAH75849 D86043 BAA12974 DA471662 DN989886 DQ891651 ABM82577 U06681 U06701 Y10375 CAA71403 Y11047 CAA71944 XM_005260669 XP_005260726 XM_005260670 XP_005260727 XM_006723545 XP_006723608 XM_006723546 XP_006723609 XM_006723547 XP_006723610 XM_011529172 XP_011527474 XM_011529173 XP_011527475 NM_001040022 NP_001035111 NM_001040023 NP_001035112 NM_080792 NP_542970
Function	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. {ECO:0000250, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIRPA 293T Cell Transient Overexpression Lysate(Denatured) - H00140885-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SIRPA overexpression lysate - LY421878 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

SIRPA overexpression lysate - LY421879 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

SIRPA overexpression lysate - LY425671 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SIRPA 293 Cell Lysate - 409581 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

SIRPA 293 Cell Lysate - 404855 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SIRP alpha/CD172a Overexpression Lysate (Native) - NBL1-15971 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

SIRP alpha/CD172a Overexpression Lysate (Native) - NBP2-05765 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SIRP-α (h): 293T Lysate - sc-159295 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SIRPA Over-expression Lysate Product - GWB-56DD89 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

SIRPA Over-expression Lysate Product - GWB-35801D from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human SIRP alpha / CD172a HEK293 Cell Lysate (WB positive control) - 11612-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

SIRP alpha/CD172a Overexpression Lysate (Native) - NBP2-10624 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

SIRP alpha/CD172a Overexpression Lysate (Native) - NBP2-11199 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SIRP alpha/CD172a Overexpression Lysate (Denatured) - H00140885-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human SIRPA Human Cells Transfected Lysate (positive control) (denatured) - orb173463 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human SIRPA Knockdown Stable Cell Line - CSC-DC014262 from Creative biogene Category Cell Line Species Human

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