SIRPA

Gene Symbol	SIRPA
Entrez Gene	140885
Alt Symbol	BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
Species	Human
Gene Type	protein-coding
Description	signal-regulatory protein alpha
Other Description	CD172 antigen-like family member A|brain-immunoglobulin-like molecule with tyrosine-based activation motifs|inhibitory receptor SHPS-1|macrophage fusion receptor|myd-1 antigen|tyrosine phosphatase SHP substrate 1|tyrosine-protein phosphatase non-receptor type substrate 1
Swissprots	Q9Y4U9 O43799 A8K411 Q9H0Z2 Q8N517 Q8TAL8 O00683 Q9UDX2 A2A2E1 P78324 B2R6C3 Q9UIJ6
Accessions	EAX10606 EAX10607 EAX10608 EAX10609 EAX10610 EAX10611 P78324 AB023430 BAA87929 AK290776 BAF83465 AK298243 BAG60509 AK312521 BAG35420 BC026692 AAH26692 BC033092 AAH33092 BC038510 AAH38510 BC075849 AAH75849 D86043 BAA12974 DA471662 DN989886 DQ891651 ABM82577 U06681 U06701 Y10375 CAA71403 Y11047 CAA71944 XM_005260669 XP_005260726 XM_005260670 XP_005260727 XM_006723545 XP_006723608 XM_006723546 XP_006723609 XM_006723547 XP_006723610 XM_011529172 XP_011527474 XM_011529173 XP_011527475 NM_001040022 NP_001035111 NM_001040023 NP_001035112 NM_080792 NP_542970
Function	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. {ECO:0000250, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIRP alpha full length protein - ab131795 from Abcam Category Protein Source Wheat germ Species Human

Human SIRP alpha protein fragment - ab151920 from Abcam Category Protein Source HEK 293 cells Species Human

Human SIRP alpha protein fragment - ab174006 from Abcam Category Protein Source HEK 293 cells Species Human

SIRP alpha peptide - ab8386 from Abcam Category Peptide

SIRPA / CD172a Antibody Blocking Peptide - LS-E10602 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRPA / CD172a Antibody Blocking Peptide - LS-E29844 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SIRP alpha/CD172a Recombinant Protein - H00140885-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SIRP alpha/CD172a Blocking Peptide - NBP1-77045PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

SIRP alpha/CD172a Recombinant Protein - H00140885-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

SIRPA-Antibody-C-term-Blocking-Peptide - BP17203b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRP alpha peptide - GTX28386 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Recombinant Human SIRP alpha/CD172a Fc Chimera, CF - 4546-SA-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

SIRPA Protein Lysate (APL10169) - APL10169 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SIRPA Protein Lysate (APL10170) - APL10170 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SIRPA Protein Lysate (APL10537) - APL10537 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SIRPA Protein Lysate (APL10538) - APL10538 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human CD172a protein - orb49655 from Biorbyt Category Protein Prices $255.00, $349.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human SIRPA protein - orb246231 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

SIRPA Blocking Peptide - 33R-7762 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIRPA protein (His tag) - 80R-3944 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

CD172a Blocking Peptide - abx064065 from Abbexa Category Peptide Species Human, Monkey

CD172a / SIRPA (27-373, His-tag) - AR51631PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CD172a / SIRPA (27-373, His-tag) - AR51631PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CD172a / SIRPA - H00140885-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD172a / SIRPA - H00140885-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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