SIRPA

Gene Symbol SIRPA
Entrez Gene 140885
Alt Symbol BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
Species Human
Gene Type protein-coding
Description signal-regulatory protein alpha
Other Description CD172 antigen-like family member A|brain-immunoglobulin-like molecule with tyrosine-based activation motifs|inhibitory receptor SHPS-1|macrophage fusion receptor|myd-1 antigen|tyrosine phosphatase SHP substrate 1|tyrosine-protein phosphatase non-receptor type substrate 1
Swissprots Q9Y4U9 O43799 A8K411 Q9H0Z2 Q8N517 Q8TAL8 O00683 Q9UDX2 A2A2E1 P78324 B2R6C3 Q9UIJ6
Accessions EAX10606 EAX10607 EAX10608 EAX10609 EAX10610 EAX10611 P78324 AB023430 BAA87929 AK290776 BAF83465 AK298243 BAG60509 AK312521 BAG35420 BC026692 AAH26692 BC033092 AAH33092 BC038510 AAH38510 BC075849 AAH75849 D86043 BAA12974 DA471662 DN989886 DQ891651 ABM82577 U06681 U06701 Y10375 CAA71403 Y11047 CAA71944 XM_005260669 XP_005260726 XM_005260670 XP_005260727 XM_006723545 XP_006723608 XM_006723546 XP_006723609 XM_006723547 XP_006723610 XM_011529172 XP_011527474 XM_011529173 XP_011527475 NM_001040022 NP_001035111 NM_001040023 NP_001035112 NM_080792 NP_542970
Function Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. {ECO:0000250, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
Top Pathways Osteoclast differentiation

SIRPα/SHPS1 (D6I3M) Rabbit mAb - 13379 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6I3M
Western blot analysis of extracts from various cell lines using SIRPα/SHPS1 (D6I3M) Rabbit mAb (upper) and GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower).

SIRP-α (C-7) - sc-376884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRP-α (C-7): sc-376884. Western blot analysis of SIRP-α expression in non-transfected: sc-117752 (A) and human SIRP-α transfected: sc-159295 (B) 293T whole cell lysates.

SIRP-α (27) - sc-136067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
SIRP-α (27): sc-136067. Western blot analysis of SIRP-α expression in rat cerebrum tissue extract.

SIRP-α1 (C-20) - sc-6922 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIRP-α (C-20): sc-6922. Western blot analysis of SIRP-α expression in non-transfected: sc-117752 (A) and human SIRP-α transfected: sc-159295 (B) 293T whole cell lysates.

SIRP-α1 (SE7C2) - sc-23863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRP-α1 (SE7C2): sc-23863. Western blot analysis of human recombinant SIRP-α1 fusion protein (A) and SIRP-α1 expression in HL-60 (B), THP-1 (C) and human peripheral blood (D) whole cell lysates.

SIRP-α/β (A-1) - sc-17803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRP-α/β (A-1): sc-17803. Western blot analysis of SIRP-α/β expression in HL-60 (A,D), THP-1 (B,E) and human PBL (C,F) whole cell lysates under reducing (A,B,C) and non-reducing (D,E,F) conditions.

SIRP-α/β (148) - sc-53605 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRP-α/β (148): sc-53605. Western blot analysis of human recombinant SIRP-α/β fusion protein (A) and SIRP-α/β expression in HL-60 (B), THP-1 (C) and human peripheral blood (D) whole cell lysates.

SIRP-α/β1 (E-7) - sc-55491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRP-α/β1 (E-7): sc-55491. Western blot analysis of SIRP-α/β1 expression in THP-1 (A), AML-193 (B) and HL-60 (C) whole cell lysates.

SIRP-α/β1 (H-300) - sc-11374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of human recombinant SIRP-α/β1 fusion protein. Antibodies tested include SIRP-α/β1 (H-300): sc-11374 (A) and SIRP-α/β1 (N-19): sc-6921 (B).

Anti-SIRP alpha antibody - ab53721 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIRP alpha antibody (ab53721) at 1/500 dilutionLane 1 : Extracts from HepG2 cellsLane 2 : Extracts from HepG2 cells with immunizing peptide

Anti-SIRP alpha antibody - ab8120 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRP alpha antibody (ab8120) at 1/2000 dilution + THP-1 whole cell lysate

Anti-SIRP alpha antibody - ab126157 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRP alpha antibody (ab126157) at 1/1000 dilution + HL-60 whole cell lysate at 30 µg

Anti-SIRP alpha antibody - ab77061 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SIRP alpha antibody (ab77061) at 1 µg/mlLane 1 : SIRP alpha transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Anti-SIRP alpha antibody [EPR16264] - ab191419 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16264
All lanes : Anti-SIRP alpha antibody [EPR16264] (ab191419) at 1/5000 dilutionLane 1 : THP1 cell lysateLane 2 : SW480 cell lysateLane 3 : Human fetal brain lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-SIRPA / CD172a Antibody IHC-plus™ - LS-B9485 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CD172A / SIRPA antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SIRPA / CD172a Antibody (clone 7B3) - LS-C340387 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B3
IHC of paraffin-embedded Human prostate tissue using anti-SIRPA mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0)(1:150).

Anti-SIRPA / CD172a Antibody (C-Terminus) IHC-plus™ - LS-B551 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRPA antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B551 concentration 5 ug/ml.

Anti-SIRPA / CD172a Antibody (aa451-500) IHC-plus™ - LS-B7618 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRPA antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7618 concentration 10 ug/ml.

Anti-SIRPA / CD172a Antibody (C-Terminus) - LS-C10167 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRPA / CD172a Antibody - LS-C10170 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal

Anti-SIRPA / CD172a Antibody (aa487-503) - LS-C10168 from LifeSpan Bioscience

Prices $345.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRPA / CD172a Antibody - LS-C10169 from LifeSpan Bioscience

Prices $650.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal

Anti-SIRPA / CD172a Antibody (Azide-free) - LS-C10171 from LifeSpan Bioscience

Prices $845.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal

Anti-SIRPA / CD172a Antibody (FITC) - LS-C10172 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SIRPA / CD172a Antibody (PE) - LS-C10173 from LifeSpan Bioscience

Prices $485.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
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