| Gene Symbol |
SLC17A5
|
| Entrez Gene |
26503
|
| Alt Symbol |
AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 17 (acidic sugar transporter), member 5
|
| Other Description |
H(+)/nitrate cotransporter|H(+)/sialic acid cotransporter|membrane glycoprotein HP59|sialic acid storage disease|sialin|sodium/sialic acid cotransporter|solute carrier family 17 (anion/sugar transporter), member 5|vesicular H(+)/Aspartate-glutamate cotransporter
|
| Swissprots |
Q5SZ76 Q9UGH0 Q9NRA2 Q8NBR5
|
| Accessions |
EAW48756 EAW48757 EAW48758 Q9NRA2 AF244577 AAF97769 AJ387747 CAB62540 AK025880 AK026921 AK075320 BAC11546 AK294068 BAG57413 AK315789 BAG38135 BC020961 AAH20961 BP288187 DQ891462 ABM82388 EU176585 ABW03386 XM_005248710 XP_005248767 XM_005248711 XP_005248768 XM_011535750 XP_011534052 XM_011535751 XP_011534053 NM_012434 NP_036566
|
| Function |
Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519, ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:21781115, ECO:0000269|PubMed:22778404}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519}.
|
| Top Pathways |
Lysosome
|