SLC17A5

Gene Symbol SLC17A5
Entrez Gene 26503
Alt Symbol AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
Species Human
Gene Type protein-coding
Description solute carrier family 17 (acidic sugar transporter), member 5
Other Description H(+)/nitrate cotransporter|H(+)/sialic acid cotransporter|membrane glycoprotein HP59|sialic acid storage disease|sialin|sodium/sialic acid cotransporter|solute carrier family 17 (anion/sugar transporter), member 5|vesicular H(+)/Aspartate-glutamate cotransporter
Swissprots Q5SZ76 Q9UGH0 Q9NRA2 Q8NBR5
Accessions EAW48756 EAW48757 EAW48758 Q9NRA2 AF244577 AAF97769 AJ387747 CAB62540 AK025880 AK026921 AK075320 BAC11546 AK294068 BAG57413 AK315789 BAG38135 BC020961 AAH20961 BP288187 DQ891462 ABM82388 EU176585 ABW03386 XM_005248710 XP_005248767 XM_005248711 XP_005248768 XM_011535750 XP_011534052 XM_011535751 XP_011534053 NM_012434 NP_036566
Function Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519, ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:21781115, ECO:0000269|PubMed:22778404}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane; Multi-pass membrane protein.
Tissue Specificity Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519}.
Top Pathways Lysosome

Sialin (H-90) - sc-134856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Sialin (H-90): sc-134856. Western blot analysis of Sialin expression in A549 (A), HCT-116 (B) and Caki-1 (C) whole cell lysates.

Sialin (V-18) - sc-50977 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sialin (V-18): sc-50977. Western blot analysis of Sialin expression in THP-1 whole cell lysate.

Sialin (S-17) - sc-50975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sialin (S-17): sc-50975. Western blot analysis of Sialin expression in Jurkat whole cell lysate.

Anti-SLC17A5 antibody - ab153920 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC17A5 antibody (ab153920) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-SLC17A5 antibody - ab69819 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC17A5 antibody (ab69819) at 0.5 µg/ml + Transfected 293T cell lysate at 10 µg with 5% skim milk / PBS bufferSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SLC17A5 antibody - ab174759 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-SLC17A5 antibody (ab174759) at 1 µg/ml + Human Placenta lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-SLC17A5 Antibody (aa146-405, Biotin) - LS-C300211 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC17A5 Antibody (aa146-405, FITC) - LS-C303150 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC17A5 Antibody (aa146-405) - LS-C294027 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SLC17A5.

Anti-SLC17A5 Antibody (aa85-99) - LS-C186601 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
SLC17A5 antibody (1 ug/ml) staining of Human Placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SLC17A5 Antibody (aa151-200) - LS-C80622 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
SLC17A5 antibody LS-C80622 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-SLC17A5 Antibody - LS-C179266 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Sialin/SLC17A5 Antibody - NBP1-59788 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Sialin/SLC17A5 Antibody [NBP1-59788] - Titration: 0.5ug/ml Positive Control: 293T cells lysate.

Sialin/SLC17A5 Antibody - NBP2-20383 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SLC17A5 Antibody [NBP2-20383] - Sample (30 ug of whole cell lysate) A: Jurkat 10% SDS PAGE gel, diluted at 1:1000.

Sialin/SLC17A5 Antibody - NBP2-13316 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SLC17A5 Antibody [NBP2-13316] Staining of human tonsil shows strong cytoplasmic positivity in subsets of germinal center cells.

Anti-SLC17A5 antibody produced in rabbit - HPA044479 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SLC17A5:<B>Cat. No. HPA044479</B>: Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of germinal center cells.

SLC17A5 antibody - N-terminal region (ARP43932_P050) - ARP43932_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

sialin--SLC17A5-aa85-99-Antibody-internal-region - AF3945a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3945a (1 µg/ml) staining of Human Placenta lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat anti-sialin / SLC17A5 (aa85-99) middle region Antibody (OAEB03119) - OAEB03119 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

SLC17A5 antibody - 70R-6694 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SLC17A5 antibody - 70R-20304 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

SLC17A5 / Sialin (85-99) antibody - AP32721PU-N from Acris Antibodies

Prices $330.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AP32721PU-N SLC17A5 / Sialin Antibody staining of Human Placenta lysate at 1µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SLC17A5 / Sialin antibody - 13320-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
COLO 320 cells were subjected to SDS PAGE followed by western blot with 13320-1-AP(SLC17A5 antibody) at dilution of 1:300

Anti-SLC17A5 Antibody - AC21-2923 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SLC17A5 Antibody (AMCA) - AC21-2923-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Search more