SLC17A5

Gene Symbol SLC17A5
Entrez Gene 26503
Alt Symbol AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
Species Human
Gene Type protein-coding
Description solute carrier family 17 (acidic sugar transporter), member 5
Other Description H(+)/nitrate cotransporter|H(+)/sialic acid cotransporter|membrane glycoprotein HP59|sialic acid storage disease|sialin|sodium/sialic acid cotransporter|solute carrier family 17 (anion/sugar transporter), member 5|vesicular H(+)/Aspartate-glutamate cotransporter
Swissprots Q5SZ76 Q9UGH0 Q9NRA2 Q8NBR5
Accessions EAW48756 EAW48757 EAW48758 Q9NRA2 AF244577 AAF97769 AJ387747 CAB62540 AK025880 AK026921 AK075320 BAC11546 AK294068 BAG57413 AK315789 BAG38135 BC020961 AAH20961 BP288187 DQ891462 ABM82388 EU176585 ABW03386 XM_005248710 XP_005248767 XM_005248711 XP_005248768 XM_011535750 XP_011534052 XM_011535751 XP_011534053 NM_012434 NP_036566
Function Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519, ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:21781115, ECO:0000269|PubMed:22778404}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane; Multi-pass membrane protein.
Tissue Specificity Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519}.
Top Pathways Lysosome

Sialin CRISPR/Cas9 KO Plasmid (h) - sc-407783 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sialin HDR Plasmid (h) - sc-407783-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sialin Double Nickase Plasmid (h) - sc-407783-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sialin Double Nickase Plasmid (h2) - sc-407783-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sialin CRISPR Activation Plasmid (h) - sc-407783-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sialin CRISPR Activation Plasmid (h2) - sc-407783-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sialin Lentiviral Activation Particles (h) - sc-407783-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sialin Lentiviral Activation Particles (h2) - sc-407783-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sialin siRNA (h) - sc-61545 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sialin shRNA Plasmid (h) - sc-61545-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sialin shRNA (h) Lentiviral Particles - sc-61545-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sialin/SLC17A5 RNAi - H00026503-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU069721 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2380 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2380 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10277 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10277

SLC17A5 siRNA (Human) - CRH8834 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC17A5 - MBS8238777 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC17A5 (NM_012434.4) - SHH408764 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLC17A5 siRNA - orb269336 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC17A5 shRNA Plasmid (Human) - CHH8834 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC17A5 miRNA 3'UTR clone - MiUTR3H-06714 from Creative biogene

Species Reactivities Human
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