SLC17A5

Gene Symbol	SLC17A5
Entrez Gene	26503
Alt Symbol	AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
Species	Human
Gene Type	protein-coding
Description	solute carrier family 17 (acidic sugar transporter), member 5
Other Description	H(+)/nitrate cotransporter|H(+)/sialic acid cotransporter|membrane glycoprotein HP59|sialic acid storage disease|sialin|sodium/sialic acid cotransporter|solute carrier family 17 (anion/sugar transporter), member 5|vesicular H(+)/Aspartate-glutamate cotransporter
Swissprots	Q5SZ76 Q9UGH0 Q9NRA2 Q8NBR5
Accessions	EAW48756 EAW48757 EAW48758 Q9NRA2 AF244577 AAF97769 AJ387747 CAB62540 AK025880 AK026921 AK075320 BAC11546 AK294068 BAG57413 AK315789 BAG38135 BC020961 AAH20961 BP288187 DQ891462 ABM82388 EU176585 ABW03386 XM_005248710 XP_005248767 XM_005248711 XP_005248768 XM_011535750 XP_011534052 XM_011535751 XP_011534053 NM_012434 NP_036566
Function	Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519, ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:21781115, ECO:0000269|PubMed:22778404}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane; Multi-pass membrane protein.
Tissue Specificity	Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLC17A5 peptide - ab178604 from Abcam Category Peptide Species Human

SLC17A5 Antibody Blocking Peptide - LS-E16147 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLC17A5 Antibody Blocking Peptide - LS-E28053 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Glutamate Oxaloacetate Transaminase protein - 30-1117 from Fitzgerald Category Protein Prices $180.00 Sizes 100 units Species Human

Glutamate Oxaloacetate Transaminase protein - 30-1116 from Fitzgerald Category Protein Prices $180.00 Sizes 100 units Species Human

SLC17A5 Blocking Peptide - 33R-4951 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human AST Protein - abx065357 from Abbexa Category Protein Source E.coli Species Human

SLC17A5 Peptide - AC21-2923-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Anion/Sugar Transporter (AST), Human - 20-8920 from ARP American Research Products Category Protein Prices $565.00 Sizes 50 µg Source E.coli Species Human

SLC17A5 fusion protein - ag3855 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Anion/Sugar Transporter (AST) - RPE379Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Anion/Sugar Transporter (AST) - RPE379Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Beta-1,4-N-Acetyl Galactosaminyl Transferase 2 (b4GALNT2) - RPJ572Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Anion/Sugar Transporter (AST), Recombinant Protein - MBS2010220 from MyBioSource Category Protein Prices $265.00, $490.00, $715.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

sialin/SLC17A5, Peptide - MBS427781 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Sialin/SLC17A5 Protein - NBP2-13316PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SLC17A5 Peptide, Human - M34GP14352H from Creative Peptides Category Peptide Source Synthetic. Species Human

SLC17A5 Recombinant Protein (OPCD01512) - OPCD01512 from Aviva Systems Biology Category Protein Source E.coli Species Human

Sialin (SLC17A5), Recombinant Protein - MBS7101946 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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