Gene Symbol | PTGR2 |
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Entrez Gene | 145482 |
Alt Symbol | HEL-S-298, PGR2, ZADH1 |
Species | Human |
Gene Type | protein-coding |
Description | prostaglandin reductase 2 |
Other Description | 15-oxoprostaglandin 13-reductase|15-oxoprostaglandin-delta13-reductase|PRG-2|epididymis secretory protein Li 298|zinc binding alcohol dehydrogenase, domain containing 1|zinc-binding alcohol dehydrogenase domain-containing protein 1 |
Swissprots | Q3L8A4 Q6MZH8 Q8N8N7 |
Accessions | EAW81132 EAW81133 EAW81134 EAW81135 Q8N8N7 AK096410 BAC04781 AK309188 AK311280 AY346133 AAR05101 AY424308 AAR82927 BC059364 AAH59364 BP357520 BU616297 BX641118 CAE46055 DR158023 FJ224334 ACI46026 HQ448502 ADQ32982 NM_001146154 NP_001139626 NM_001146155 NP_001139627 NM_152444 NP_689657 |
Function | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:15004468}. |
ZADH1 CRISPR/Cas9 KO Plasmid (h) - sc-414552 from Santa Cruz Biotechnology
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ZADH1 HDR Plasmid (h) - sc-414552-HDR from Santa Cruz Biotechnology
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ZADH1 Double Nickase Plasmid (h) - sc-414552-NIC from Santa Cruz Biotechnology
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ZADH1 Double Nickase Plasmid (h2) - sc-414552-NIC-2 from Santa Cruz Biotechnology
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ZADH1 CRISPR Activation Plasmid (h) - sc-414552-ACT from Santa Cruz Biotechnology
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ZADH1 CRISPR Activation Plasmid (h2) - sc-414552-ACT-2 from Santa Cruz Biotechnology
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ZADH1 Lentiviral Activation Particles (h) - sc-414552-LAC from Santa Cruz Biotechnology
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ZADH1 Lentiviral Activation Particles (h2) - sc-414552-LAC-2 from Santa Cruz Biotechnology
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ZADH1 siRNA (h) - sc-92364 from Santa Cruz Biotechnology
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ZADH1 shRNA Plasmid (h) - sc-92364-SH from Santa Cruz Biotechnology
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ZADH1 shRNA (h) Lentiviral Particles - sc-92364-V from Santa Cruz Biotechnology
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ZADH1 RNAi - H00145482-R01 from Novus Biologicals
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MISSION® esiRNA - EHU035631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17675 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17675 from Sigma-Aldrich
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PTGR2 siRNA (Human) - CRJ5433 from Cohesion Biosciences
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shRNA set against Human PTGR2 (NM_152444.2) - SHH386124 from Creative biogene
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PTGR2 shRNA Plasmid (Human) - CHJ5433 from Cohesion Biosciences
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PTGR2 miRNA 3'UTR clone - MiUTR3H-10128 from Creative biogene
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PTGR2 miRNA 3'UTR clone - MiUTR3H-10129 from Creative biogene
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PTGR2 miRNA 3'UTR clone - MiUTR3H-10130 from Creative biogene
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