SOCS7

Gene Symbol SOCS7
Entrez Gene 30837
Alt Symbol NAP4, NCKAP4
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 7
Other Description NAP-4|NCK-associated protein 4|Nck, Ash and phospholipase C binding protein|SOCS-7|nck, Ash and phospholipase C gamma-binding protein
Swissprots Q0IJ63 O14512 A2VCU2
Accessions EAW60512 O14512 AA233668 AB005216 BAA22432 AI223248 AK094338 AW613025 BC121030 BC121031 BC128607 AAI28608 BC167822 AAI67822 DQ593634 NM_014598 NP_055413
Function Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
Tissue Specificity Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain. {ECO:0000269|PubMed:9344857}.
Top Pathways Jak-STAT signaling pathway, Prolactin signaling pathway

SOCS-7 (E-8) - sc-137241 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SOCS-7 (E-8): sc-137241. Western blot analysis of SOCS-7 expression in Jurkat whole cell lysate.

SOCS-7 (C-19) - sc-8291 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SOCS-7 (H-112) - sc-5609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SOCS-7 (H-112): sc-5609. Western blot analysis of human recombinant SOCS-7 fusion protein.

SOCS-7 (N-19) - sc-8290 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SOCS7 antibody - ab80603 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SOCS7 antibody (ab80603) at 1 µg/ml + Daudi lysate (in RIPA buffer) at 35 µg

Anti-SOCS7 antibody - ab130611 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SOCS7 antibody (ab130611) at 1/100 dilution + Hela cell line lysate at 35 µg

Anti-SOCS7 antibody - ab13951 from Abcam

Prices $235.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 antibody [EPR8466] - ab133677 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8466
All lanes : Anti-SOCS7 antibody [EPR8466] (ab133677) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLane 4 : U-87 MG cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SOCS7 antibody - N-terminal - ab198266 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling SOCS7 with ab198266 at 1/30 dilution.

Anti-SOCS7 antibody - N-terminal - ab182348 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SOCS7 antibody - N-terminal (ab182348) at 1 µg/ml + Human breast tumor tissue lysate at 10 µgSecondaryGoat anti-rabbit IgG HRP conjugated antibody at 1/15000 dilutiondeveloped using the ECL technique

Anti-SOCS7 / SOCS-7 Antibody (C-Terminus) - LS-C189203 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody - LS-C189204 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody (aa458-486, AP) - LS-C269935 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody (aa458-486, APC) - LS-C269936 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody (aa458-486, Biotin) - LS-C269937 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody (aa458-486, Azide-free, HRP) - LS-C269938 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody (aa458-486, FITC) - LS-C269939 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody (aa458-486, PE) - LS-C269940 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody (aa457-486) - LS-C325270 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS7 / SOCS-7 Antibody (aa35-84) - LS-C111539 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SOCS7 antibody LS-C111539 Western blot of OVCAR-3 cell lysate.

Anti-SOCS7 / SOCS-7 Antibody (aa458-486) - LS-C161384 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SOCS7 Antibody western blot of HeLa cell line lysates (35 ug/lane). The SOCS7 antibody detected the SOCS7 protein (arrow).

Anti-SOCS7 / SOCS-7 Antibody (N-Terminus, clone EPR8466) - LS-C154623 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8466
IHC of paraffin-embedded human brain tissue using anti-SOCS7 antibody.

Anti-SOCS7 / SOCS-7 Antibody (aa3-52) - LS-C205799 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SOCS7 / SOCS-7 antibody Western Blot of Breast Tumor. Antibody dilution: 1 ug/ml.

Anti-SOCS7 / SOCS-7 Antibody (aa10-22) - LS-C87362 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (1 ug/ml) staining of Daudi lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

SOCS-7/Nck/NAP4 Antibody (519106) - MAB5809 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 519106
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and MCF‑7 human breast cancer cell line. PVDF membrane was probed with 0.5 µg/mL of Human SOCS‑7/Nck/NAP4 Monoclonal Antibody (Catalog # MAB5809) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for SOCS‑7/Nck/NAP4 at approximately 63 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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