| Gene Symbol |
SOCS7
|
| Entrez Gene |
30837
|
| Alt Symbol |
NAP4, NCKAP4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of cytokine signaling 7
|
| Other Description |
NAP-4|NCK-associated protein 4|Nck, Ash and phospholipase C binding protein|SOCS-7|nck, Ash and phospholipase C gamma-binding protein
|
| Swissprots |
Q0IJ63 O14512 A2VCU2
|
| Accessions |
EAW60512 O14512 AA233668 AB005216 BAA22432 AI223248 AK094338 AW613025 BC121030 BC121031 BC128607 AAI28608 BC167822 AAI67822 DQ593634 NM_014598 NP_055413
|
| Function |
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
|
| Tissue Specificity |
Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain. {ECO:0000269|PubMed:9344857}.
|
| Top Pathways |
Jak-STAT signaling pathway, Prolactin signaling pathway
|