SOCS7

Gene Symbol SOCS7
Entrez Gene 30837
Alt Symbol NAP4, NCKAP4
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 7
Other Description NAP-4|NCK-associated protein 4|Nck, Ash and phospholipase C binding protein|SOCS-7|nck, Ash and phospholipase C gamma-binding protein
Swissprots Q0IJ63 O14512 A2VCU2
Accessions EAW60512 O14512 AA233668 AB005216 BAA22432 AI223248 AK094338 AW613025 BC121030 BC121031 BC128607 AAI28608 BC167822 AAI67822 DQ593634 NM_014598 NP_055413
Function Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
Tissue Specificity Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain. {ECO:0000269|PubMed:9344857}.
Top Pathways Jak-STAT signaling pathway, Prolactin signaling pathway

Human SOCS7 protein fragment - ab162327 from Abcam

Category Protein
Source Wheat germ
Species Human
ab162327 on a 12.5% SDS-PAGE stained with Coomassie Blue.

SOCS7-Antibody-C-term-Blocking-Peptide - BP17111b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

SOCS7 Peptide - AC21-1711-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

SOCS7 / NAP4 - H00030837-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

SOCS7 / NAP4 - H00030837-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

SOCS7 Peptide - 46-764P from ProSci

Category Peptide
Species Human

Recombinant Human Suppressor of cytokine signaling 7(SOCS7) - CSB-YP022396HU CSB-EP022396HU CSB-BP022396HU CSB-MP022396HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

SOCS7, Peptide - MBS659939 from MyBioSource

Category Peptide
Prices $340.00
Sizes 100 µg
Species Human

SOCS7, Peptide - MBS425955 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human

Suppressor of cytokine signaling 7 (SOCS7), Recombinant Protein - MBS1052046 from MyBioSource

Category Protein
Prices $1,380.00, $1,380.00, $1,600.00, $1,600.00, $2,300.00, $2,300.00, $2,745.00, $2,745.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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