SOCS7

Gene Symbol SOCS7
Entrez Gene 30837
Alt Symbol NAP4, NCKAP4
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 7
Other Description NAP-4|NCK-associated protein 4|Nck, Ash and phospholipase C binding protein|SOCS-7|nck, Ash and phospholipase C gamma-binding protein
Swissprots Q0IJ63 O14512 A2VCU2
Accessions EAW60512 O14512 AA233668 AB005216 BAA22432 AI223248 AK094338 AW613025 BC121030 BC121031 BC128607 AAI28608 BC167822 AAI67822 DQ593634 NM_014598 NP_055413
Function Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
Tissue Specificity Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain. {ECO:0000269|PubMed:9344857}.
Top Pathways Jak-STAT signaling pathway, Prolactin signaling pathway

SOCS-7 CRISPR/Cas9 KO Plasmid (h) - sc-405246 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-7 HDR Plasmid (h) - sc-405246-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-7 Double Nickase Plasmid (h) - sc-405246-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-7 Double Nickase Plasmid (h2) - sc-405246-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-7 CRISPR Activation Plasmid (h) - sc-405246-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-7 CRISPR Activation Plasmid (h2) - sc-405246-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-7 Lentiviral Activation Particles (h) - sc-405246-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-7 Lentiviral Activation Particles (h2) - sc-405246-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-7 siRNA (h) - sc-41004 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SOCS-7 shRNA Plasmid (h) - sc-41004-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SOCS-7 shRNA (h) Lentiviral Particles - sc-41004-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU038691 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20326 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20326 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02091 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02091

SOCS7 siRNA (Human) - CRH9354 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOCS7 - MBS8213164 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SOCS7 (NM_014598.2) - SHH415008 from Creative biogene

Category siRNA
Species Reactivities Human

Human SOCS7 siRNA - orb269856 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOCS7 shRNA Plasmid (Human) - CHH9354 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SOCS7 miRNA 3'UTR clone - MiUTR3H-10230 from Creative biogene

Species Reactivities Human
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