TP53INP1

Gene Symbol TP53INP1
Entrez Gene 94241
Alt Symbol SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1
Species Human
Gene Type protein-coding
Description tumor protein p53 inducible nuclear protein 1
Other Description p53-dependent damage-inducible nuclear protein 1|p53-inducible p53DINP1|stress-induced protein|tumor protein p53-inducible nuclear protein 1
Swissprots Q969R9 B2RCE5 Q96A56
Accessions BAB62151 BAB62152 EAW91739 EAW91740 EAW91741 Q96A56 AB017926 BAB62149 AB017927 BAB62150 AF409114 AAL04513 AF409115 AAL04514 AK025792 AK123608 AK125880 AK130074 AK315071 BAG37542 AL133074 AL833652 BC074813 AAH74813 BC074868 AAH74868 DB086880 XM_011517386 XP_011515688 NM_001135733 NP_001129205 NM_033285 NP_150601
Function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by
Subcellular Location Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:12067065}.
Top Pathways HTLV-I infection

TP53INP1 (H-110) - sc-68919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TP53INP1 (H-110): sc-68919. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic staining of glandular cells.

TP53INP1 (S-18) - sc-79751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TP53INP1 (T-17) - sc-79752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-p53 DINP1 antibody - ab9775 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of p53DINP1 expression in human lung tissue lysate with anti-p53DINP1 (ab9775) at 2 µg/ml in the absence (lane 1) or presence (lane 2) of blocking peptide (ab9776).

Anti-p53 DINP1 antibody - ab154877 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-p53 DINP1 antibody (ab154877) at 1 µg/ml (Milk blocking - 3%) + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 20 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-p53 DINP1 antibody - ab125960 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-p53 DINP1 antibody (ab125960) at 1 µg/ml + Lung (Human) Tissue Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-p53 DINP1 antibody [EPR17974] - ab202026 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17974
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized HepG2 (Human liver hepatocellular carcinoma) cells labeling p53 DINP1 with ab202026 at 1/300 dilution, followed by Goat anti-rabbit IgG (Alexa Fluor® 488) (ab150077) secondary antibody at 1/500 dilution (green).Confocal image showing nuclear staining on HepG2 cells.The nuclear counter stain is DAPI (blue).Tubulin is detected with ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution and ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution (red).The negative controls are as follows:-ve control 1: ab202026 at 1/300 dilution followed by ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution.-ve control 2: ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution followed by ab150077 (Alexa Fluor®488 Goat Anti-Rabbit IgG H&L) at 1/500 dilution. 

Anti-p53 DINP1 antibody - Aminoterminal end - ab137360 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-p53 DINP1 antibody - Aminoterminal end (ab137360) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-SIP / TP53INP1 Antibody (aa1-14) - LS-C25915 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (N-Terminus) - LS-C48323 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa1-14) - LS-C83545 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa181-210, AP) - LS-C242010 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa181-210, APC) - LS-C242011 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody - LS-C770 from LifeSpan Bioscience

Prices $335.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot of p53DINP1 expression in mouse spleen using antibody at 1:5000 dilution.

Anti-SIP / TP53INP1 Antibody (aa181-210, Biotin) - LS-C242012 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa181-210, FITC) - LS-C242013 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa181-210, PE) - LS-C242014 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa36-64, AP) - LS-C242015 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa36-64, Biotin) - LS-C242016 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa36-64, APC) - LS-C242017 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody - LS-C178474 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa36-64, FITC) - LS-C242018 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (C-Terminus) - LS-C134911 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TP53INP1 antibody LS-C134911 Western blot of MCF7 cell lysate.

Anti-SIP / TP53INP1 Antibody (aa36-64, PE) - LS-C242022 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIP / TP53INP1 Antibody (aa181-210, Azide-free, HRP) - LS-C247108 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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