TP53INP1

Gene Symbol	TP53INP1
Entrez Gene	94241
Alt Symbol	SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1
Species	Human
Gene Type	protein-coding
Description	tumor protein p53 inducible nuclear protein 1
Other Description	p53-dependent damage-inducible nuclear protein 1|p53-inducible p53DINP1|stress-induced protein|tumor protein p53-inducible nuclear protein 1
Swissprots	Q969R9 B2RCE5 Q96A56
Accessions	BAB62151 BAB62152 EAW91739 EAW91740 EAW91741 Q96A56 AB017926 BAB62149 AB017927 BAB62150 AF409114 AAL04513 AF409115 AAL04514 AK025792 AK123608 AK125880 AK130074 AK315071 BAG37542 AL133074 AL833652 BC074813 AAH74813 BC074868 AAH74868 DB086880 XM_011517386 XP_011515688 NM_001135733 NP_001129205 NM_033285 NP_150601
Function	Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by
Subcellular Location	Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:12067065}.
Top Pathways	HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human p53 DINP1 peptide - ab9776 from Abcam Category Peptide Species Human

p53 DINP1 Blocking Peptide - NBP1-76638PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TP53INP1-Antibody-C-term-Blocking-peptide - BP11890b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TP53INP1-Antibody-N-term-Blocking-peptide - BP11742a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TP53INP1 Blocking Peptide - 33R-3390 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TP53INP1 Blocking Peptide - abx064032 from Abbexa Category Peptide Species Human, Monkey

TP53INP1 Control Peptide - AP30639CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

p53DINP1 Peptide - 3045P from ProSci Category Peptide Species Human

TP53INP1 fusion protein - Ag12358 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TP53INP1 fusion protein - Ag12608 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human TP53INP1, GST-tagged - TP53INP1-3364H from Creative Biomart Category Protein Source E.coli Species Human

TP53INP1 Blocking Peptide - CBP2838 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

Recombinant Human Tumor protein p53-inducible nuclear protein 1(TP53INP1) - CSB-YP822174HU CSB-EP822174HU CSB-BP822174HU CSB-MP822174HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

p53DINP1 Blocking Peptide - 3340BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

p53 DINP1 peptide - ab206313 from Abcam Category Peptide

TP53INP1 Peptide - abx164713 from Abbexa Category Peptide Species Human, Mouse, Rat

p53DINP1, Peptide - MBS843629 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

Synthetic Human BAFFR (aa 169-183)(CT) Blocking Peptide - PX232BP from Cell Science Category Peptide Prices $170.00 Sizes 50 μg Species Human

Synthetic Human TP53INP1 (aa 1-14) Blocking Peptide - PX229BP from Cell Science Category Peptide Prices $170.00 Sizes 50 μg Species Human

p53 DINP1 Recombinant Protein Antigen - NBP1-85108PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TP53INP1 Peptide, Human - M34GP16459H from Creative Peptides Category Peptide Source Synthetic. Species Human

TP53INP1 peptide - orb218701 from Biorbyt Category Peptide

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