| Gene Symbol | TP53INP1 |
|---|---|
| Entrez Gene | 94241 |
| Alt Symbol | SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor protein p53 inducible nuclear protein 1 |
| Other Description | p53-dependent damage-inducible nuclear protein 1|p53-inducible p53DINP1|stress-induced protein|tumor protein p53-inducible nuclear protein 1 |
| Swissprots | Q969R9 B2RCE5 Q96A56 |
| Accessions | BAB62151 BAB62152 EAW91739 EAW91740 EAW91741 Q96A56 AB017926 BAB62149 AB017927 BAB62150 AF409114 AAL04513 AF409115 AAL04514 AK025792 AK123608 AK125880 AK130074 AK315071 BAG37542 AL133074 AL833652 BC074813 AAH74813 BC074868 AAH74868 DB086880 XM_011517386 XP_011515688 NM_001135733 NP_001129205 NM_033285 NP_150601 |
| Function | Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by |
| Subcellular Location | Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:12067065}. |
| Top Pathways | HTLV-I infection |
TP53INP1 CRISPR/Cas9 KO Plasmid (h) - sc-402835 from Santa Cruz Biotechnology
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TP53INP1 HDR Plasmid (h) - sc-402835-HDR from Santa Cruz Biotechnology
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TP53INP1 Double Nickase Plasmid (h) - sc-402835-NIC from Santa Cruz Biotechnology
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TP53INP1 Double Nickase Plasmid (h2) - sc-402835-NIC-2 from Santa Cruz Biotechnology
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TP53INP1 CRISPR Activation Plasmid (h) - sc-402835-ACT from Santa Cruz Biotechnology
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TP53INP1 CRISPR Activation Plasmid (h2) - sc-402835-ACT-2 from Santa Cruz Biotechnology
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TP53INP1 Lentiviral Activation Particles (h) - sc-402835-LAC from Santa Cruz Biotechnology
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TP53INP1 Lentiviral Activation Particles (h2) - sc-402835-LAC-2 from Santa Cruz Biotechnology
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TP53INP1 siRNA (h) - sc-76715 from Santa Cruz Biotechnology
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TP53INP1 shRNA Plasmid (h) - sc-76715-SH from Santa Cruz Biotechnology
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TP53INP1 shRNA (h) Lentiviral Particles - sc-76715-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU044501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21848 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21848 from Sigma-Aldrich
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TP53INP1 siRNA (Human) - CRJ4264 from Cohesion Biosciences
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TP53INP1 - MBS8214000 from MyBioSource
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TP53INP1 shRNA Plasmid (Human) - CHJ4264 from Cohesion Biosciences
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