| Gene Symbol |
TP53INP1
|
| Entrez Gene |
94241
|
| Alt Symbol |
SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor protein p53 inducible nuclear protein 1
|
| Other Description |
p53-dependent damage-inducible nuclear protein 1|p53-inducible p53DINP1|stress-induced protein|tumor protein p53-inducible nuclear protein 1
|
| Swissprots |
Q969R9 B2RCE5 Q96A56
|
| Accessions |
BAB62151 BAB62152 EAW91739 EAW91740 EAW91741 Q96A56 AB017926 BAB62149 AB017927 BAB62150 AF409114 AAL04513 AF409115 AAL04514 AK025792 AK123608 AK125880 AK130074 AK315071 BAG37542 AL133074 AL833652 BC074813 AAH74813 BC074868 AAH74868 DB086880 XM_011517386 XP_011515688 NM_001135733 NP_001129205 NM_033285 NP_150601
|
| Function |
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:12067065}.
|
| Top Pathways |
HTLV-I infection
|