| Gene Symbol |
SNCG
|
| Entrez Gene |
6623
|
| Alt Symbol |
BCSG1, SR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
synuclein, gamma (breast cancer-specific protein 1)
|
| Other Description |
breast cancer-specific gene 1 protein|gamma-synuclein|persyn|synoretin
|
| Swissprots |
O15104 Q96P61 O76070
|
| Accessions |
AAC27738 AAC36586 EAW80315 EAW80316 EAW80317 EAW80318 O76070 AF010126 AAB64109 AF017256 AAC36550 AF411524 AAL05870 AK223367 BAD97087 AK312141 BAG35077 BC014098 AAH14098 BP346786 CR541788 CAG46587 CR541790 CAG46589 DQ892334 ABM83260 DQ892505 ABM83431 DQ895719 ABM86645 EU019993 ABS18760 EU176715 ABW03516 XM_011540105 XP_011538407 NM_003087 NP_003078
|
| Function |
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11746666}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
|
| Tissue Specificity |
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
|