Gene Symbol | SNCG |
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Entrez Gene | 6623 |
Alt Symbol | BCSG1, SR |
Species | Human |
Gene Type | protein-coding |
Description | synuclein, gamma (breast cancer-specific protein 1) |
Other Description | breast cancer-specific gene 1 protein|gamma-synuclein|persyn|synoretin |
Swissprots | O15104 Q96P61 O76070 |
Accessions | AAC27738 AAC36586 EAW80315 EAW80316 EAW80317 EAW80318 O76070 AF010126 AAB64109 AF017256 AAC36550 AF411524 AAL05870 AK223367 BAD97087 AK312141 BAG35077 BC014098 AAH14098 BP346786 CR541788 CAG46587 CR541790 CAG46589 DQ892334 ABM83260 DQ892505 ABM83431 DQ895719 ABM86645 EU019993 ABS18760 EU176715 ABW03516 XM_011540105 XP_011538407 NM_003087 NP_003078 |
Function | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11746666}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. |
Tissue Specificity | Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. |
γ-synuclein CRISPR/Cas9 KO Plasmid (h) - sc-401050 from Santa Cruz Biotechnology
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γ-synuclein HDR Plasmid (h) - sc-401050-HDR from Santa Cruz Biotechnology
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γ-synuclein Double Nickase Plasmid (h) - sc-401050-NIC from Santa Cruz Biotechnology
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γ-synuclein Double Nickase Plasmid (h2) - sc-401050-NIC-2 from Santa Cruz Biotechnology
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γ-synuclein CRISPR Activation Plasmid (h) - sc-401050-ACT from Santa Cruz Biotechnology
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γ-synuclein CRISPR Activation Plasmid (h2) - sc-401050-ACT-2 from Santa Cruz Biotechnology
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γ-synuclein Lentiviral Activation Particles (h) - sc-401050-LAC from Santa Cruz Biotechnology
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γ-synuclein Lentiviral Activation Particles (h2) - sc-401050-LAC-2 from Santa Cruz Biotechnology
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γ-synuclein siRNA (h) - sc-42289 from Santa Cruz Biotechnology
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γ-synuclein shRNA Plasmid (h) - sc-42289-SH from Santa Cruz Biotechnology
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γ-synuclein shRNA (h) Lentiviral Particles - sc-42289-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU041881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19863 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19863 from Sigma-Aldrich
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SNCG siRNA (Human) - CRH4506 from Cohesion Biosciences
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gamma-Synuclein RNAi - H00006623-R01 from Novus Biologicals
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SNCG - MBS8217672 from MyBioSource
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shRNA set against Human SNCG (NM_003087.2) - SHH414028 from Creative biogene
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γ-synuclein CRISPR/Cas9 KO Plasmid (h2) - sc-401050-KO-2 from Santa Cruz Biotechnology
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γ-synuclein HDR Plasmid (h2) - sc-401050-HDR-2 from Santa Cruz Biotechnology
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SNCG shRNA Plasmid (Human) - CHH4506 from Cohesion Biosciences
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SNCG miRNA 3'UTR clone - MiUTR3H-05530 from Creative biogene
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