LGR4

Gene Symbol	LGR4
Entrez Gene	55366
Alt Symbol	BNMD17, GPR48
Species	Human
Gene Type	protein-coding
Description	leucine-rich repeat containing G protein-coupled receptor 4
Other Description	G protein-coupled receptor 48|leucine-rich repeat-containing G-protein coupled receptor 4
Swissprots	A6NCH3 Q8N537 G5E9B3 Q9BXB1 Q9NYD1
Accessions	AAK31153 EAW68285 EAW68286 Q9BXB1 AB209743 BAD92980 AF257182 AAF68989 AI699025 BC033039 AAH33039 CB047435 DQ892475 ABM83401 DQ895687 ABM86613 NM_018490 NP_060960
Function	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal c
Subcellular Location	Cell membrane {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}; Multi-pass membrane protein {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}.
Tissue Specificity	Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Leucine-rich repeat-containing G-protein coupled receptor 4, LGR4, Human, ELISA Kit - E1155h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.625-40 ng/mL

G Protein Coupled Receptor 48, ELISA Kit - MBS745735 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein Coupled Receptor 48, ELISA Kit - MBS753161 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

G Protein Coupled Receptor 48, ELISA Kit - MBS750921 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein Coupled Receptor 48, ELISA Kit - MBS753767 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein Coupled Receptor 48, ELISA Kit - MBS750952 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein Coupled Receptor 48, ELISA Kit - MBS746649 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

G Protein Coupled Receptor 48, ELISA Kit - MBS750010 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein Coupled Receptor 48, ELISA Kit - MBS751818 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein Coupled Receptor 48, ELISA Kit - MBS744408 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

G Protein Coupled Receptor 48, ELISA Kit - MBS745182 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

G Protein Coupled Receptor 48, ELISA Kit - MBS746982 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

leucine-rich repeat-containing G protein-coupled receptor 4, ELISA Kit - MBS9341944 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse GPR48 / LGR4 ELISA Kit (Custom ELISA) - LS-F16221 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.625-40 ng/ml

Human GPR48 / LGR4 ELISA Kit (Custom ELISA) - LS-F16222 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.625-40 ng/ml

Rat GPR48 / LGR4 ELISA Kit (Custom ELISA) - LS-F16223 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.625-40 ng/ml

LGR4 - EKH2634 from Nordic BioSite Sensitivity 0.375ng/ml Range 0.625-40ng/ml

Human GPR48 ELISA Kit - E015783 from Biobool Category ELISA Kit

Human LGR4 ELISA Kit - E022523 from Biobool Category ELISA Kit

LGR4 ELISA Kit (Human) (OKEH04645) - OKEH04645 from Aviva Systems Biology Category ELISA Kit Prices $596.00 Sizes 96 wells Sensitivity < 0.31 ng/mL Range 0.625 - 40 ng/mL

anti-LGR4 / GPR48 antibody - ARG56874 from Arigo Biolaboratories Category ELISA Kit

Leucine-rich repeat-containing G-protein coupled receptor 4, ELISA Kit - MBS764999 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/ml Range 0.625-40ng/ml

Leucine-rich repeat-containing G-protein coupled receptor 4, ELISA Kit - MBS2886009 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.625-40 ng/mL

Human GPR48 / LGR4 ELISA Kit (Sandwich ELISA) - LS-F35955 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.375 Range 0.625-40 ng/ml

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