LGR4
| Gene Symbol | LGR4 |
|---|---|
| Entrez Gene | 55366 |
| Alt Symbol | BNMD17, GPR48 |
| Species | Human |
| Gene Type | protein-coding |
| Description | leucine-rich repeat containing G protein-coupled receptor 4 |
| Other Description | G protein-coupled receptor 48|leucine-rich repeat-containing G-protein coupled receptor 4 |
| Swissprots | A6NCH3 Q8N537 G5E9B3 Q9BXB1 Q9NYD1 |
| Accessions | AAK31153 EAW68285 EAW68286 Q9BXB1 AB209743 BAD92980 AF257182 AAF68989 AI699025 BC033039 AAH33039 CB047435 DQ892475 ABM83401 DQ895687 ABM86613 NM_018490 NP_060960 |
| Function | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal c |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}; Multi-pass membrane protein {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}. |
| Tissue Specificity | Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen. |
LGR4 CRISPR/Cas9 KO Plasmid (h) - sc-402643 from Santa Cruz Biotechnology
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LGR4 HDR Plasmid (h) - sc-402643-HDR from Santa Cruz Biotechnology
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LGR4 Double Nickase Plasmid (h) - sc-402643-NIC from Santa Cruz Biotechnology
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LGR4 Double Nickase Plasmid (h2) - sc-402643-NIC-2 from Santa Cruz Biotechnology
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LGR4 CRISPR Activation Plasmid (h) - sc-402643-ACT from Santa Cruz Biotechnology
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LGR4 CRISPR Activation Plasmid (h2) - sc-402643-ACT-2 from Santa Cruz Biotechnology
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LGR4 Lentiviral Activation Particles (h) - sc-402643-LAC from Santa Cruz Biotechnology
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LGR4 Lentiviral Activation Particles (h2) - sc-402643-LAC-2 from Santa Cruz Biotechnology
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LGR4 siRNA (h) - sc-62557 from Santa Cruz Biotechnology
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LGR4 shRNA Plasmid (h) - sc-62557-SH from Santa Cruz Biotechnology
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LGR4 shRNA (h) Lentiviral Particles - sc-62557-V from Santa Cruz Biotechnology
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Lgr4/GPR48 RNAi - H00055366-R02 from Novus Biologicals
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MISSION® esiRNA - EHU103381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11681 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10756 from Sigma-Aldrich
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LGR4 siRNA (Human) - CRJ0692 from Cohesion Biosciences
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shRNA set against Human LGR4 (NM_018490.2) - SHH329943 from Creative biogene
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shRNA set against Human LGR4(NM_018490.2) - SHH147917 from Creative biogene
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Human LGR4 siRNA - orb271193 from Biorbyt
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LGR4 shRNA Plasmid (Human) - CHJ0692 from Cohesion Biosciences
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LGR4 miRNA 3'UTR clone - MiUTR1H-05648 from Creative biogene
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