| Gene Symbol |
LGR4
|
| Entrez Gene |
55366
|
| Alt Symbol |
BNMD17, GPR48
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine-rich repeat containing G protein-coupled receptor 4
|
| Other Description |
G protein-coupled receptor 48|leucine-rich repeat-containing G-protein coupled receptor 4
|
| Swissprots |
A6NCH3 Q8N537 G5E9B3 Q9BXB1 Q9NYD1
|
| Accessions |
AAK31153 EAW68285 EAW68286 Q9BXB1 AB209743 BAD92980 AF257182 AAF68989 AI699025 BC033039 AAH33039 CB047435 DQ892475 ABM83401 DQ895687 ABM86613 NM_018490 NP_060960
|
| Function |
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal c
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}; Multi-pass membrane protein {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}.
|
| Tissue Specificity |
Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.
|