LGR4

Gene Symbol LGR4
Entrez Gene 55366
Alt Symbol BNMD17, GPR48
Species Human
Gene Type protein-coding
Description leucine-rich repeat containing G protein-coupled receptor 4
Other Description G protein-coupled receptor 48|leucine-rich repeat-containing G-protein coupled receptor 4
Swissprots A6NCH3 Q8N537 G5E9B3 Q9BXB1 Q9NYD1
Accessions AAK31153 EAW68285 EAW68286 Q9BXB1 AB209743 BAD92980 AF257182 AAF68989 AI699025 BC033039 AAH33039 CB047435 DQ892475 ABM83401 DQ895687 ABM86613 NM_018490 NP_060960
Function Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal c
Subcellular Location Cell membrane {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}; Multi-pass membrane protein {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:22815884}.
Tissue Specificity Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.

LGR4 (C-12) - sc-390630 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LGR4 (C-12): sc-390630. Western blot analysis of LGR4 expression in ES-2 whole cell lysate.

LGR4 (H-142) - sc-292344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LGR4 (H-142): sc-292344. Western blot analysis of LGR4 expression in U-937 whole cell lysate.

LGR4 (S-20) - sc-68578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LGR4 (S-20): sc-68578. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and membrane localization.

LGR4 (W-17) - sc-68579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GPCR GPR48 antibody - ab75501 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GPCR GPR48 antibody (ab75501) at 1/500 dilutionLane 1 : Jurkat cell extractLane 2 : Jurkat cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-GPCR GPR48 antibody [6G8.B3.G5.C3] - ab106089 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6G8.B3.G5.C3
ab106089 at 5&microg/ml staining GPCR GPR48 in Formalin-fixed,Paraffin-embedded Human Brain cerebellum by Immunohistochemistry. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.

Anti-GPCR GPR48 antibody [BBX-3A8] - ab166659 from Abcam

Prices $376.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone BBX-3A8
Flow cytometric analysis of BOSC23 cells labeling GPCR GPR48 with ab166659 at 1.2 µg/106 cells. BOSC23 cells were transiently transfected with an expression vector encoding either Human GPCR GPR48 (red curve), Mouse GPCR GPR48 (blue curve) or an irrelevant protein (control transfectant: black curve), followed by a Phycoerythrin-conjugated secondary antibody.

Anti-GPCR GPR48 antibody - C-terminal - ab188973 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain (cortex) tissue, labeling GPCR GPR48 with ab188973 at 13 µg/ml.

Anti-GPCR GPR48 antibody - C-terminal - ab137480 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR48 antibody - C-terminal (ab137480) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-GPCR GPR48 antibody - C-terminal - ab176903 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GPCR GPR48 antibody - C-terminal (ab176903) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysate

Anti-GPCR GPR48 antibody - N-terminal - ab140845 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human caudate tissue, labeling GPCR GPR48 using ab140845 at a 4 µg/ml concentration.

Anti-GPCR GPR48 antibody - N-terminal - ab189554 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR48 antibody - N-terminal (ab189554) at 1/1000 dilution + mouse thymus extract

Anti-GPR48 / LGR4 Antibody (N-Terminus) IHC-plus™ - LS-A1631 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR48 / LGR4 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR48 / LGR4 Antibody (N-Terminus) IHC-plus™ - LS-A3561 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LGR4 antibody LS-A3561 IHC of human brain, caudate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR48 / LGR4 Antibody (clone 5B8) - LS-C173136 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LGR4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR4.

Anti-GPR48 / LGR4 Antibody (C-Terminus) IHC-plus™ - LS-A3593 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR48 / LGR4 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR48 / LGR4 Antibody (Internal) - LS-C123974 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GPR48 / LGR4 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1633 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LGR4 antibody LS-A1633 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR48 / LGR4 Antibody (clone 8F6) - LS-C139087 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8F6
Detection limit for recombinant GST tagged CNR2 is 0.1 ng/ml as a capture antibody.

Anti-GPR48 / LGR4 Antibody (aa461-510) - LS-C120733 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using LGR4 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-GPR48 / LGR4 Antibody (clone 2D1) - LS-C173125 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LGR4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR4.

Anti-GPR48 / LGR4 Antibody (C-Terminus) IHC-plus™ - LS-A3560 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LGR4 antibody LS-A3560 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Lgr4/GPR48 Antibody - NLS3593 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Lgr4/GPR48 Antibody [NLS3593] - Analysis of anti-GPR48 / LGR4 antibody with human lung, adenocarcinoma.

Lgr4/GPR48 Antibody (852229) [Unconjugated] - MAB7750 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 852229
In a functional flow cytometry test, biotinylated Recombinant Human R-Spondin 4 (100 ng/mL) binds to HEK293 human embryonic kidney cell line transfected with human Lgr4/GPR48 (dark orange histogram). Binding is completely blocked (light orange histogram) by 2.5 μg/mL of Mouse Anti-Human Lgr4/GPR48 Monoclonal Antibody (Catalog # MAB7750). Mouse IgG2B Isotype Control (Catalog # MAB004) at 2.5 μg/mL was used as a control (blue line). Cells were stained with Streptavidin-APC (Catalog # F0050).

Lgr4/GPR48 Antibody - NBP1-89737 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Lgr4/GPR48 Antibody [NBP1-89737] - Staining of human breast shows strong positivity in glandular cells.
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