Gene Symbol | FRAT1 |
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Entrez Gene | 10023 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | frequently rearranged in advanced T-cell lymphomas 1 |
Other Description | FRAT-1|proto-oncogene FRAT1 |
Swissprots | Q5JTI1 Q8NE74 Q8TDW9 Q92837 |
Accessions | EAW49950 EAW49951 Q92837 AB074890 BAB86352 AK307245 BC034476 AAH34476 BE041458 U58975 AAB97096 NM_005479 NP_005470 NM_181355 |
Function | Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. {ECO:0000269|PubMed:12556519}. |
Subcellular Location | Cytoplasm. |
Top Pathways | Wnt signaling pathway |
FRAT1 CRISPR/Cas9 KO Plasmid (h) - sc-406922 from Santa Cruz Biotechnology
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FRAT1 HDR Plasmid (h) - sc-406922-HDR from Santa Cruz Biotechnology
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FRAT1 Double Nickase Plasmid (h) - sc-406922-NIC from Santa Cruz Biotechnology
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FRAT1 Double Nickase Plasmid (h2) - sc-406922-NIC-2 from Santa Cruz Biotechnology
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FRAT1 CRISPR Activation Plasmid (h) - sc-406922-ACT from Santa Cruz Biotechnology
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FRAT1 CRISPR Activation Plasmid (h2) - sc-406922-ACT-2 from Santa Cruz Biotechnology
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FRAT1 Lentiviral Activation Particles (h) - sc-406922-LAC from Santa Cruz Biotechnology
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FRAT1 Lentiviral Activation Particles (h2) - sc-406922-LAC-2 from Santa Cruz Biotechnology
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FRAT1 siRNA (h) - sc-105373 from Santa Cruz Biotechnology
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FRAT1 shRNA Plasmid (h) - sc-105373-SH from Santa Cruz Biotechnology
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FRAT1 shRNA (h) Lentiviral Particles - sc-105373-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8931 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10058 from Sigma-Aldrich
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FRAT1 siRNA (Human) - CRH6750 from Cohesion Biosciences
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FRAT1 - MBS8212394 from MyBioSource
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shRNA set against Human FRAT1 (NM_005479.3) - SHH297009 from Creative biogene
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FRAT1 CRISPR/Cas9 KO Plasmid (h2) - sc-406922-KO-2 from Santa Cruz Biotechnology
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FRAT1 HDR Plasmid (h2) - sc-406922-HDR-2 from Santa Cruz Biotechnology
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FRAT1 shRNA Plasmid (Human) - CHH6750 from Cohesion Biosciences
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FRAT1 miRNA 3'UTR clone - MiUTR3H-05037 from Creative biogene
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