Gene Symbol | F7 |
---|---|
Entrez Gene | 2155 |
Alt Symbol | SPCA |
Species | Human |
Gene Type | protein-coding |
Description | coagulation factor VII (serum prothrombin conversion accelerator) |
Other Description | FVII coagulation protein|coagulation factor VII|eptacog alfa|proconvertin |
Swissprots | Q5JVF1 Q9UD53 Q9UD52 Q9UD54 Q5JVF2 B0YJC8 P08709 Q14339 |
Accessions | AAA51983 AAC50211 AAL66184 AAP33841 ABD17891 ABO20833 ABO20834 ACA06107 ACA06108 CAL24227 CCQ42967 EAX09182 EAX09183 P08709 AI076552 AK298404 BAG60634 AK310779 AK311565 AK311682 AY423856 AAQ94106 BC130468 AAI30469 CB156039 DB184045 EF421855 ABN79862 EU557239 ACB87203 HQ258414 ADR83168 M13232 AAA88040 XM_006719963 XP_006720026 XM_011537474 XP_011535776 XM_011537475 XP_011535777 XM_011537476 XP_011535778 XM_011537477 XP_011535779 NM_000131 NP_000122 NM_001267554 NP_001254483 NM_019616 NP_062562 NR_051961 |
Function | Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. |
Subcellular Location | Secreted. |
Tissue Specificity | Plasma. |
Top Pathways | Complement and coagulation cascades |