Gene Symbol | MESP2 |
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Entrez Gene | 145873 |
Alt Symbol | SCDO2, bHLHc6 |
Species | Human |
Gene Type | protein-coding |
Description | mesoderm posterior basic helix-loop-helix transcription factor 2 |
Other Description | class C basic helix-loop-helix protein 6|mesoderm posterior 2 homolog|mesoderm posterior protein 2 |
Swissprots | Q0VG99 Q7RTU2 |
Accessions | DAA00304 Q0VG99 AL360139 BC111413 AAI11414 NM_001039958 NP_001035047 |
Function | Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. |
MESP2 (C-19) - sc-164985 from Santa Cruz Biotechnology
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MESP2 (V-14) - sc-164989 from Santa Cruz Biotechnology
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Anti-Mesp2 antibody - ab200690 from Abcam
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Anti-Mesp2 antibody [1B3F9] - ab166702 from Abcam
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MESP2 Antibody (1B3F9) - NBP2-37424 from Novus Biologicals
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MESP2 Antibody (1C8) - H00145873-M01 from Novus Biologicals
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MESP2 Antibody (1E11) - H00145873-M03 from Novus Biologicals
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Monoclonal Anti-MESP2 antibody produced in mouse - SAB1405366 from Sigma-Aldrich
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Monoclonal Anti-MESP2 antibody produced in mouse - WH0145873M1 from Sigma-Aldrich
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MEF2C-Antibody - AO1786a from Abgent, a WuXi AppTec company
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MESP2 antibody [N2C3] - GTX110174 from GeneTex
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MESP2 antibody [1B3F9] - GTX60671 from GeneTex
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Anti -MESP2 - 030443 from USBiological Life Science
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Anti -MESP2 (Mesoderm Posterior Protein 2, Class C Basic Helix-loop-helix Protein 6,bHLHc6, BHLHC6, SCDO2) - 129592 from USBiological Life Science
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Anti -MESP2 (Mesoderm Posterior Protein 2, Class C Basic Helix-loop-helix Protein 6,bHLHc6, BHLHC6, SCDO2) (AP) - 129592-AP from USBiological Life Science
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Anti -MESP2 (Mesoderm Posterior Protein 2, Class C Basic Helix-loop-helix Protein 6,bHLHc6, BHLHC6, SCDO2) (Biotin) - 129592-Biotin from USBiological Life Science
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Anti -MESP2 (Mesoderm Posterior Protein 2, Class C Basic Helix-loop-helix Protein 6,bHLHc6, BHLHC6, SCDO2) (FITC) - 129592-FITC from USBiological Life Science
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Anti -MESP2 (Mesoderm Posterior Protein 2, Class C Basic Helix-loop-helix Protein 6,bHLHc6, BHLHC6, SCDO2) (HRP) - 129592-HRP from USBiological Life Science
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Anti -MESP2 (Mesoderm Posterior Protein 2, Class C Basic Helix-loop-helix Protein 6,bHLHc6, BHLHC6, SCDO2) (PE) - 129592-PE from USBiological Life Science
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MESP2 antibody - abx011989 from Abbexa
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MESP2 Antibody - abx121160 from Abbexa
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MESP2 Antibody - abx032591 from Abbexa
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MESP2 antibody - 21648-1-AP from Acris Antibodies
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MESP2 antibody - H00145873-M01 from Acris Antibodies
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MESP2 antibody - H00145873-M03 from Acris Antibodies
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