| Gene Symbol |
MESP2
|
| Entrez Gene |
145873
|
| Alt Symbol |
SCDO2, bHLHc6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mesoderm posterior basic helix-loop-helix transcription factor 2
|
| Other Description |
class C basic helix-loop-helix protein 6|mesoderm posterior 2 homolog|mesoderm posterior protein 2
|
| Swissprots |
Q0VG99 Q7RTU2
|
| Accessions |
DAA00304 Q0VG99 AL360139 BC111413 AAI11414 NM_001039958 NP_001035047
|
| Function |
Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
|