Gene Symbol | CLPP |
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Entrez Gene | 8192 |
Alt Symbol | DFNB81, PRLTS3 |
Species | Human |
Gene Type | protein-coding |
Description | caseinolytic mitochondrial matrix peptidase proteolytic subunit |
Other Description | ATP-dependent Clp protease proteolytic subunit, mitochondrial|ATP-dependent protease ClpAP, proteolytic subunit, human|ClpP caseinolytic peptidase ATP-dependent, proteolytic subunit|ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog|ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog|endopeptidase Clp|putative ATP-dependent Clp protease proteolytic subunit, mitochondrial |
Swissprots | B2R4W5 Q16740 |
Accessions | EAW69103 Q16740 AK311973 BAG34912 BC002956 AAH02956 BF339807 DQ895823 ABM86749 EF036491 ABO65077 EU176368 ABW03819 Z50853 CAA90705 NM_006012 NP_006003 |
Function | Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:15522782}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:10525407}. |
Tissue Specificity | Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney. {ECO:0000269|PubMed:10525407, ECO:0000269|PubMed:8543061}. |
Human CLPP full length protein - ab124872 from Abcam
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Human CLPP peptide - ab23265 from Abcam
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CLPP Antibody Blocking Peptide - LS-E25507 from LifeSpan Bioscience
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CLPP Antibody Blocking Peptide - LS-E23083 from LifeSpan Bioscience
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CLPP Partial Recombinant Protein - H00008192-Q01 from Novus Biologicals
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CLPP Recombinant Protein - H00008192-P01 from Novus Biologicals
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Recombinant Human CLPP Protein - NBP1-72319 from Novus Biologicals
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CLPP blocking peptide - GTX15708-PEP from GeneTex
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Human CLPP protein - orb168130 from Biorbyt
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CLPP protein - 30R-2073 from Fitzgerald
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CLPP Peptide - AC21-0335-P from Abcore
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CLPP (57-277) - AR39013PU-L from Acris Antibodies
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CLPP (57-277) - AR39013PU-N from Acris Antibodies
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CLPP - H00008192-P01-10 from Acris Antibodies
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CLPP - H00008192-P01-25 from Acris Antibodies
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CLPP - H00008192-Q01-10 from Acris Antibodies
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CLPP - H00008192-Q01-25 from Acris Antibodies
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ClpP Caseinolytic Peptidase, Human Recombinant - 228-12267-1 from RayBiotech
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CLPP, 57-277aa, Human, E.coli - 01-P1073 from ARP American Research Products
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CLPP Peptide - 45-406P from ProSci
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CLPP fusion protein - Ag8325 from Proteintech Group
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CLPP fusion protein - Ag8420 from Proteintech Group
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CLPP Human - ENPS-122 from NeoScientific
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CLPP, 57-277aa, Recombinant Protein - GWB-P0965C from Genway Biotech
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CLPP Human Protein - GWB-BSP151 from Genway Biotech
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