Gene Symbol | CLPP |
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Entrez Gene | 8192 |
Alt Symbol | DFNB81, PRLTS3 |
Species | Human |
Gene Type | protein-coding |
Description | caseinolytic mitochondrial matrix peptidase proteolytic subunit |
Other Description | ATP-dependent Clp protease proteolytic subunit, mitochondrial|ATP-dependent protease ClpAP, proteolytic subunit, human|ClpP caseinolytic peptidase ATP-dependent, proteolytic subunit|ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog|ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog|endopeptidase Clp|putative ATP-dependent Clp protease proteolytic subunit, mitochondrial |
Swissprots | B2R4W5 Q16740 |
Accessions | EAW69103 Q16740 AK311973 BAG34912 BC002956 AAH02956 BF339807 DQ895823 ABM86749 EF036491 ABO65077 EU176368 ABW03819 Z50853 CAA90705 NM_006012 NP_006003 |
Function | Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:15522782}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:10525407}. |
Tissue Specificity | Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney. {ECO:0000269|PubMed:10525407, ECO:0000269|PubMed:8543061}. |
CLPP Antibody - 14181 from Cell Signaling Technology
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ClpP (B-12) - sc-271284 from Santa Cruz Biotechnology
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ClpP (C-17) - sc-47845 from Santa Cruz Biotechnology
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ClpP (FL-277) - sc-134496 from Santa Cruz Biotechnology
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ClpP (E-19) - sc-47846 from Santa Cruz Biotechnology
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ClpP (P-15) - sc-47847 from Santa Cruz Biotechnology
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ClpP (Q-20) - sc-47848 from Santa Cruz Biotechnology
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Anti-CLPP antibody - ab56455 from Abcam
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Anti-CLPP antibody - ab126102 from Abcam
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Anti-CLPP antibody - ab15708 from Abcam
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Anti-CLPP antibody - ab96672 from Abcam
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Anti-CLPP antibody [1E2] - ab119065 from Abcam
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Anti-CLPP antibody [EPR7133] - ab124822 from Abcam
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Anti-CLPP Antibody (aa178-278, clone 10B2264, Azide-free) - LS-C183522 from LifeSpan Bioscience
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Anti-CLPP Antibody (aa196-245) - LS-C151516 from LifeSpan Bioscience
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Anti-CLPP Antibody (Internal, clone EPR7133) - LS-C138964 from LifeSpan Bioscience
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Anti-CLPP Antibody (clone 1D8) - LS-C115827 from LifeSpan Bioscience
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Anti-CLPP Antibody (clone 1E2) - LS-C337161 from LifeSpan Bioscience
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Anti-CLPP Antibody (clone 1C7) - LS-C172469 from LifeSpan Bioscience
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Anti-CLPP Antibody (clone 1G9) - LS-C172470 from LifeSpan Bioscience
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Anti-CLPP Antibody (clone 1F6) - LS-C172471 from LifeSpan Bioscience
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Anti-CLPP Antibody - LS-C155399 from LifeSpan Bioscience
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Anti-CLPP Antibody (clone 3E2) - LS-C133541 from LifeSpan Bioscience
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Anti-CLPP Antibody (C-Terminus) IHC-plus™ - LS-B2749 from LifeSpan Bioscience
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Anti-CLPP Antibody (aa215-277) IHC-plus™ - LS-B12082 from LifeSpan Bioscience
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