CLPP
| Gene Symbol | CLPP |
|---|---|
| Entrez Gene | 8192 |
| Alt Symbol | DFNB81, PRLTS3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | caseinolytic mitochondrial matrix peptidase proteolytic subunit |
| Other Description | ATP-dependent Clp protease proteolytic subunit, mitochondrial|ATP-dependent protease ClpAP, proteolytic subunit, human|ClpP caseinolytic peptidase ATP-dependent, proteolytic subunit|ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog|ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog|endopeptidase Clp|putative ATP-dependent Clp protease proteolytic subunit, mitochondrial |
| Swissprots | B2R4W5 Q16740 |
| Accessions | EAW69103 Q16740 AK311973 BAG34912 BC002956 AAH02956 BF339807 DQ895823 ABM86749 EF036491 ABO65077 EU176368 ABW03819 Z50853 CAA90705 NM_006012 NP_006003 |
| Function | Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:15522782}. |
| Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:10525407}. |
| Tissue Specificity | Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney. {ECO:0000269|PubMed:10525407, ECO:0000269|PubMed:8543061}. |
ClpP CRISPR/Cas9 KO Plasmid (h) - sc-403092 from Santa Cruz Biotechnology
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ClpP HDR Plasmid (h) - sc-403092-HDR from Santa Cruz Biotechnology
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ClpP Double Nickase Plasmid (h) - sc-403092-NIC from Santa Cruz Biotechnology
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ClpP Double Nickase Plasmid (h2) - sc-403092-NIC-2 from Santa Cruz Biotechnology
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ClpP CRISPR Activation Plasmid (h) - sc-403092-ACT from Santa Cruz Biotechnology
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ClpP CRISPR Activation Plasmid (h2) - sc-403092-ACT-2 from Santa Cruz Biotechnology
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ClpP Lentiviral Activation Particles (h) - sc-403092-LAC from Santa Cruz Biotechnology
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ClpP Lentiviral Activation Particles (h2) - sc-403092-LAC-2 from Santa Cruz Biotechnology
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ClpP siRNA (h) - sc-60413 from Santa Cruz Biotechnology
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ClpP shRNA Plasmid (h) - sc-60413-SH from Santa Cruz Biotechnology
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ClpP shRNA (h) Lentiviral Particles - sc-60413-V from Santa Cruz Biotechnology
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CLPP RNAi - H00008192-R01 from Novus Biologicals
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MISSION® esiRNA - EHU011941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6256 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6256 from Sigma-Aldrich
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CLPP siRNA (Human) - CRH5391 from Cohesion Biosciences
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CLPP - MBS8238397 from MyBioSource
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shRNA set against Human CLPP (NM_006012.2) - SHH265589 from Creative biogene
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shRNA set against Human CLPP(NM_006012.2) - SHG183925 from Creative biogene
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Human CLPP siRNA - orb265893 from Biorbyt
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CLPP shRNA Plasmid (Human) - CHH5391 from Cohesion Biosciences
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CLPP miRNA 3'UTR clone - MiUTR1H-02234 from Creative biogene
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