| Gene Symbol | WIPI2 |
|---|---|
| Entrez Gene | 26100 |
| Alt Symbol | ATG18B, Atg21, CGI-50, WIPI-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | WD repeat domain, phosphoinositide interacting 2 |
| Other Description | WD repeat domain phosphoinositide-interacting protein 2|WD40 repeat protein interacting with phosphoinositides 2|WIPI49-like protein 2 |
| Swissprots | Q9Y4P8 Q9Y364 B3KNC2 Q5MNZ8 Q96IE4 Q75L50 Q6FI96 |
| Accessions | AAQ96865 AAQ96866 AAQ96867 EAW87324 EAW87325 EAW87326 EAW87327 EAW87328 Q9Y4P8 AF151808 AAD34045 AI074985 AK023041 BAG51152 AK024279 BAG51284 AK124974 BAC86012 AK125007 AK315468 AL080155 CAB45746 AM392901 CAL37779 AM393618 CAL38494 AM393628 CAL38504 AY691425 AAV80761 AY691426 AAV80762 BC004116 AAH04116 BC007596 AAH07596 BC016912 BC021012 BC021068 BC021200 AAH21200 BI561383 BX537624 CAH56163 CR533530 CAG38561 XM_006715685 XP_006715748 NM_001033518 NP_001028690 NM_001033519 NP_001028691 NM_001033520 NP_001028692 NM_001278299 NP_001265228 NM_015610 NP_056425 NM_016003 NP_057087 |
| Function | Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P. {ECO:0000269|PubMed:20505359}. |
| Subcellular Location | Preautophagosomal structure membrane {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:23916833}; Peripheral membrane protein {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}; Cytoplasmic side {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269|PubMed:24954904}. |
| Tissue Specificity | Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. {ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20505359}. |
WIPI2 - MBS1267278 from MyBioSource
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Human WIPI2 cDNA clone(NM_001033518.1) - CDFH021280 from Creative Biomart
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Human WIPI2 cDNA clone(NM_001033519.1) - CDFH021281 from Creative Biomart
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Human WIPI2 cDNA clone(NM_001033520.1) - CDFH021282 from Creative Biomart
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Human WIPI2 cDNA clone(NM_015610.3) - CDFH021284 from Creative Biomart
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Human WIPI2 cDNA clone(NM_016003.3) - CDFH021285 from Creative Biomart
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Human WIPI2 ORF Clone(NM_015610.3) - CDCL181312 from Creative Biomart
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Human WIPI2 ORF Clone(NM_001033518.1) - CDCL181313 from Creative Biomart
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human WIPI2 ORF clone - CDCH101350 from Creative Biomart
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human WIPI2 ORF clone - CDCH101351 from Creative Biomart
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human WIPI2 ORF clone - CDCH101352 from Creative Biomart
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human WIPI2 ORF clone - CDCH101353 from Creative Biomart
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human WIPI2 ORF clone - CDCH101354 from Creative Biomart
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human WIPI2 ORF clone - CDCH101355 from Creative Biomart
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human WIPI2 ORF clone - CDCH101356 from Creative Biomart
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human WIPI2 ORF clone - CDCH101357 from Creative Biomart
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human WIPI2 ORF clone - CDCH101358 from Creative Biomart
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human WIPI2 ORF clone - CDCH101359 from Creative Biomart
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Human WIPI2 ORF Clone(NM_015610.3) - CDCR299785 from Creative Biomart
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Human WIPI2 ORF Clone(NM_015610.3) - CDCR299786 from Creative Biomart
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Human WIPI2 ORF Clone(NM_015610.3) - CDCR299787 from Creative Biomart
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Human WIPI2 ORF Clone(NM_016003.3) - CDCR300315 from Creative Biomart
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Human WIPI2 ORF Clone(NM_016003.3) - CDCR300316 from Creative Biomart
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Human WIPI2 ORF Clone(NM_001033518.1) - CDCR343121 from Creative Biomart
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Human WIPI2 ORF Clone(NM_001033518.1) - CDCR343122 from Creative Biomart
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