WIPI2

Gene Symbol WIPI2
Entrez Gene 26100
Alt Symbol ATG18B, Atg21, CGI-50, WIPI-2
Species Human
Gene Type protein-coding
Description WD repeat domain, phosphoinositide interacting 2
Other Description WD repeat domain phosphoinositide-interacting protein 2|WD40 repeat protein interacting with phosphoinositides 2|WIPI49-like protein 2
Swissprots Q9Y4P8 Q9Y364 B3KNC2 Q5MNZ8 Q96IE4 Q75L50 Q6FI96
Accessions AAQ96865 AAQ96866 AAQ96867 EAW87324 EAW87325 EAW87326 EAW87327 EAW87328 Q9Y4P8 AF151808 AAD34045 AI074985 AK023041 BAG51152 AK024279 BAG51284 AK124974 BAC86012 AK125007 AK315468 AL080155 CAB45746 AM392901 CAL37779 AM393618 CAL38494 AM393628 CAL38504 AY691425 AAV80761 AY691426 AAV80762 BC004116 AAH04116 BC007596 AAH07596 BC016912 BC021012 BC021068 BC021200 AAH21200 BI561383 BX537624 CAH56163 CR533530 CAG38561 XM_006715685 XP_006715748 NM_001033518 NP_001028690 NM_001033519 NP_001028691 NM_001033520 NP_001028692 NM_001278299 NP_001265228 NM_015610 NP_056425 NM_016003 NP_057087
Function Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P. {ECO:0000269|PubMed:20505359}.
Subcellular Location Preautophagosomal structure membrane {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:23916833}; Peripheral membrane protein {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}; Cytoplasmic side {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269|PubMed:24954904}.
Tissue Specificity Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. {ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20505359}.

WIPI-2 CRISPR/Cas9 KO Plasmid (h) - sc-411876 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WIPI-2 HDR Plasmid (h) - sc-411876-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WIPI-2 Double Nickase Plasmid (h) - sc-411876-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WIPI-2 Double Nickase Plasmid (h2) - sc-411876-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WIPI-2 CRISPR Activation Plasmid (h) - sc-411876-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WIPI-2 CRISPR Activation Plasmid (h2) - sc-411876-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WIPI-2 Lentiviral Activation Particles (h) - sc-411876-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WIPI-2 Lentiviral Activation Particles (h2) - sc-411876-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WIPI-2 siRNA (h) - sc-72212 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WIPI-2 shRNA Plasmid (h) - sc-72212-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WIPI-2 shRNA (h) Lentiviral Particles - sc-72212-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU095551 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22904 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11858 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11858

WIPI2 siRNA (Human) - CRH8711 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

WIPI2 - MBS8207190 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human WIPI2 (NM_015610.3) - SHH447084 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human WIPI2(NM_001033520.1) - SHL135210 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human WIPI2(NM_001033518.1) - SHL135246 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human WIPI2(NM_015610.3) - SHL135264 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human WIPI2(NM_001033519.1) - SHL135282 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human WIPI2(NM_016003.3) - SHL135336 from Creative biogene

Category siRNA
Species Reactivities Human

WIPI2 shRNA Plasmid (Human) - CHH8711 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

WIPI2 miRNA 3'UTR clone - MiUTR1H-11266 from Creative biogene

Species Reactivities Human
Search more