| Gene Symbol |
MCM10
|
| Entrez Gene |
55388
|
| Alt Symbol |
CNA43, DNA43, PRO2249
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex component 10
|
| Other Description |
MCM10 minichromosome maintenance deficient 10|homolog of yeast MCM10|hsMCM10|protein MCM10 homolog
|
| Swissprots |
Q7L590 Q96GX4 Q3MIR3 A8K9I6 Q9H3P9 Q96NB6 B7ZKZ8 Q7LD55 Q9P177 Q9H0D7
|
| Accessions |
AAB34309 AAB34784 EAW86297 EAW86298 Q7L590 AB042719 BAB18723 AF119869 AAF69623 AK055695 BAB70988 AK292701 BAF85390 AL136840 CAB66774 BC004876 AAH04876 BC009108 BC101727 AAI01728 BC143490 AAI43491 DA024424 XM_011519538 XP_011517840 NM_018518 NP_060988 NM_182751 NP_877428
|
| Function |
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575}. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.
|