MARCH1

Gene Symbol	MARCH1
Entrez Gene	55016
Alt Symbol	MARCH-I, RNF171
Species	Human
Gene Type	protein-coding
Description	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MARCH1|RING finger protein 171|membrane-associated RING finger protein 1|membrane-associated RING-CH protein I
Swissprots	D3DP29 Q8TCQ1 Q9NWR0
Accessions	EAX04834 EAX04835 Q8TCQ1 AK000675 BAA91319 AK025005 AK091335 AK289711 BAF82400 AK301408 BAH13475 AL713759 CAD28529 AV716666 AW118953 BC148531 AAI48532 BC153124 AAI53125 XM_011532055 XP_011530357 XM_011532056 XP_011530358 NM_001166373 NP_001159845 NM_017923 NP_060393
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940}.
Subcellular Location	Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17255932}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MARCH1 (C-13) - sc-104368 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MARCH1 (D-16) - sc-104369 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MARCH1 (P-15) - sc-104371 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-MARCH-I antibody - ab123393 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MARCH-I antibody [EPR14923] - ab187667 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14923

Anti-MARCH1 Antibody (aa50-61) - LS-C61763 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-MARCH1 Antibody (aa163-191, APC) - LS-C237385 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MARCH1 Antibody (aa163-191, Biotin) - LS-C237386 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MARCH1 Antibody (aa163-191, AP) - LS-C237387 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MARCH1 Antibody (aa163-191, FITC) - LS-C237389 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MARCH1 Antibody (aa163-191, PE) - LS-C237390 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MARCH1 Antibody (aa163-191, Azide-free, HRP) - LS-C248762 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MARCH1 Antibody (aa1-100) - LS-C308892 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MARCH1 Antibody (aa145-174) - LS-C322847 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MARCH1 Antibody (aa36-85) - LS-C102010 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MARCH1 Antibody (aa163-191) - LS-C164032 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

MARCH1 Antibody - NBP1-59758 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MARCH1 Antibody - NBP1-91637 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MARCH1 Antibody - H00055016-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

MARCH1 Antibody (3D2) - H00055016-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D2

Rabbit Anti-MARCH1 Polyclonal Antibody - bs-9335R from Bioss Prices $245.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MARCH1 antibody produced in rabbit - HPA014600 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-MARCH1 antibody produced in mouse - WH0055016M2 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D2

Anti-MARCH1 antibody produced in rabbit - SAB2101432 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

MARCH1 Antibody - N-terminal region (ARP43239_P050) - ARP43239_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Search more