| Gene Symbol |
MARCH1
|
| Entrez Gene |
55016
|
| Alt Symbol |
MARCH-I, RNF171
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase MARCH1|RING finger protein 171|membrane-associated RING finger protein 1|membrane-associated RING-CH protein I
|
| Swissprots |
D3DP29 Q8TCQ1 Q9NWR0
|
| Accessions |
EAX04834 EAX04835 Q8TCQ1 AK000675 BAA91319 AK025005 AK091335 AK289711 BAF82400 AK301408 BAH13475 AL713759 CAD28529 AV716666 AW118953 BC148531 AAI48532 BC153124 AAI53125 XM_011532055 XP_011530357 XM_011532056 XP_011530358 NM_001166373 NP_001159845 NM_017923 NP_060393
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17255932}.
|