MARCH1

Gene Symbol	MARCH1
Entrez Gene	55016
Alt Symbol	MARCH-I, RNF171
Species	Human
Gene Type	protein-coding
Description	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MARCH1|RING finger protein 171|membrane-associated RING finger protein 1|membrane-associated RING-CH protein I
Swissprots	D3DP29 Q8TCQ1 Q9NWR0
Accessions	EAX04834 EAX04835 Q8TCQ1 AK000675 BAA91319 AK025005 AK091335 AK289711 BAF82400 AK301408 BAH13475 AL713759 CAD28529 AV716666 AW118953 BC148531 AAI48532 BC153124 AAI53125 XM_011532055 XP_011530357 XM_011532056 XP_011530358 NM_001166373 NP_001159845 NM_017923 NP_060393
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940}.
Subcellular Location	Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17255932}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MARCH-I full length protein - ab162930 from Abcam Category Protein Source Wheat germ Species Human

Human MARCH-I protein fragment - ab162931 from Abcam Category Protein Source Wheat germ Species Human

MARCH1 Antibody Blocking Peptide - LS-E3193 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARCH1 Antibody Blocking Peptide - LS-E15910 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARCH1 Antibody Blocking Peptide - LS-E26597 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MARCH1 Protein - H00055016-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MARCH1 Protein - H00055016-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MARCH1-Antibody-Center-Blocking-Peptide - BP14345c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MARCH-I blocking peptide - GTX88859-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

RNF171 Blocking Peptide - 33R-5299 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MARCH-I Peptide - AC21-1433-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MARCH1 / RNF171 - H00055016-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MARCH1 / RNF171 - H00055016-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MARCH1 / RNF171 - H00055016-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MARCH1 / RNF171 - H00055016-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MARCH1 Peptide - 46-684P from ProSci Category Peptide

MARCH1 fusion protein - ag20190 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MARCH1 fusion protein - ag20231 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human 41334, His-tagged - MARCH1-744H from Creative Biomart Category Protein Source E.coli Species Human

MARCH1 Blocking Peptide - CBP4324 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

MARCH1 Blocking Peptide - abx161535 from Abbexa Category Peptide Species Human, Mouse

MARCH1 / RNF171 - H00055016-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

MARCH-I, Peptide - MBS425538 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

MARCH-I, Peptide - MBS658590 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg Species Human, Rat

MARCH1 Recombinant Protein Antigen - NBP1-91637PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Search more