MARCH1

Gene Symbol MARCH1
Entrez Gene 55016
Alt Symbol MARCH-I, RNF171
Species Human
Gene Type protein-coding
Description membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase MARCH1|RING finger protein 171|membrane-associated RING finger protein 1|membrane-associated RING-CH protein I
Swissprots D3DP29 Q8TCQ1 Q9NWR0
Accessions EAX04834 EAX04835 Q8TCQ1 AK000675 BAA91319 AK025005 AK091335 AK289711 BAF82400 AK301408 BAH13475 AL713759 CAD28529 AV716666 AW118953 BC148531 AAI48532 BC153124 AAI53125 XM_011532055 XP_011530357 XM_011532056 XP_011530358 NM_001166373 NP_001159845 NM_017923 NP_060393
Function E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17255932}.

Human MARCH1 cDNA clone(NM_001166373.1) - CDFH011076 from Creative Biomart

Species Human
Accession NM_001166373.1

Human MARCH1 ORF Clone(NM_017923.3) - CDCL169622 from Creative Biomart

Species Human
Accession NM_017923.3

Human MARCH1 ORF Clone(NM_001166373.1) - CDCR355338 from Creative Biomart

Species Human
Accession NM_001166373.1

Human MARCH1 ORF Clone(NM_001166373.1) - CDCR355340 from Creative Biomart

Species Human
Accession NM_001166373.1

Human MARCH1 ORF clone (NM_001166373.1) - CDCR038948 from Creative biogene

Species Human

Human MARCH1 cDNA Clone(NM_001166373.1) - CDFH011076 from Creative biogene

Species Human
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