EPHB1

Gene Symbol	EPHB1
Entrez Gene	2047
Alt Symbol	ELK, EPHT2, Hek6, NET
Species	Human
Gene Type	protein-coding
Description	EPH receptor B1
Other Description	EK6|EPH-like kinase 6|eph tyrosine kinase 2|ephrin type-B receptor 1|neuronally-expressed EPH-related tyrosine kinase|soluble EPHB1 variant 1|tyrosine-protein kinase receptor EPH-2
Swissprots	O95143 Q0VG87 O43569 P54762 B3KTB2 A8K593 B5A969 O95142
Accessions	CAT16944 CCF76954 EAW79127 EAW79128 EAW79129 P54762 AF037333 AAB94627 AF037334 AAB94628 AK095305 BAG53024 AK291208 BAF83897 AK309741 AW207121 BC111744 AAI11745 BM665724 DA107464 EU826607 ACF47643 L40636 AAB08520 XM_011512540 XP_011510842 XM_011512541 XP_011510843 XM_011512542 XP_011510844 NM_004441 NP_004432
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formatio
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18034775}; Single-pass type I membrane protein {ECO:0000269|PubMed:18034775}. Early endosome membrane {ECO:0000269|PubMed:18034775}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity	Preferentially expressed in brain.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EphB1 (5F10) Mouse mAb - 3980 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone 5F10

EphB1 (Q-20) - sc-926 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EphB1 (M-19) - sc-9319 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EphB1 (5F10A4) - sc-130054 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EphB1 (H-80) - sc-28979 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-Eph receptor B1 + Eph receptor B2 + Eph receptor B3 + Eph receptor B4 antibody - ab110360 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Eph receptor B1 + Eph receptor B2 (phospho Y594) antibody - ab61791 from Abcam Prices $394.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Eph receptor B1 + Eph receptor B2 antibody - ab61765 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Eph receptor B1 antibody - ab28312 from Abcam Prices $370.00 Sizes 250 µg Host Sheep Clonality Polyclonal

Anti-Eph receptor B1 antibody - ab28314 from Abcam Prices $370.00 Sizes 250 µg Host Sheep Clonality Polyclonal

Anti-Eph receptor B1 antibody - ab171814 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Eph receptor B1 antibody [5F10A4] - ab66326 from Abcam Host Mouse Clonality Monoclonal Clone 5F10A4

Anti-Eph receptor B1 antibody [EPR6457] - ab129103 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6457

Anti-EPHB1 / EPH Receptor B1 Antibody (C-Terminus) - LS-C26554 from LifeSpan Bioscience Prices $330.00 Sizes 250 µg Host Sheep Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody (N-Terminus) - LS-C26553 from LifeSpan Bioscience Prices $330.00 Sizes 250 µg Host Sheep Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody - LS-C26555 from LifeSpan Bioscience Prices $330.00 Sizes 250 µg Host Sheep Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody (aa18-538) - LS-C150294 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody (Ile874) - LS-C193186 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody (clone EfrnB1) - LS-C209599 from LifeSpan Bioscience Prices $515.00 Sizes 100 µg Host Hamster Clonality Monoclonal Clone EfrnB1

Anti-EPHB1 / EPH Receptor B1 Antibody (clone EfB1-3) - LS-C209598 from LifeSpan Bioscience Prices $515.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone EfB1-3

Anti-EPHB1 / EPH Receptor B1 Antibody (C-Terminus, APC) - LS-C219020 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody (C-Terminus, AP) - LS-C219019 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody (C-Terminus, FITC) - LS-C219022 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody (C-Terminus, Azide-free, HRP) - LS-C219023 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EPHB1 / EPH Receptor B1 Antibody (C-Terminus, Biotin) - LS-C219021 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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