| Gene Symbol | EPHB1 |
|---|---|
| Entrez Gene | 2047 |
| Alt Symbol | ELK, EPHT2, Hek6, NET |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor B1 |
| Other Description | EK6|EPH-like kinase 6|eph tyrosine kinase 2|ephrin type-B receptor 1|neuronally-expressed EPH-related tyrosine kinase|soluble EPHB1 variant 1|tyrosine-protein kinase receptor EPH-2 |
| Swissprots | O95143 Q0VG87 O43569 P54762 B3KTB2 A8K593 B5A969 O95142 |
| Accessions | CAT16944 CCF76954 EAW79127 EAW79128 EAW79129 P54762 AF037333 AAB94627 AF037334 AAB94628 AK095305 BAG53024 AK291208 BAF83897 AK309741 AW207121 BC111744 AAI11745 BM665724 DA107464 EU826607 ACF47643 L40636 AAB08520 XM_011512540 XP_011510842 XM_011512541 XP_011510843 XM_011512542 XP_011510844 NM_004441 NP_004432 |
| Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formatio |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:18034775}; Single-pass type I membrane protein {ECO:0000269|PubMed:18034775}. Early endosome membrane {ECO:0000269|PubMed:18034775}. Cell projection, dendrite {ECO:0000250}. |
| Tissue Specificity | Preferentially expressed in brain. |
| Top Pathways | Axon guidance |