EPHB1

Gene Symbol	EPHB1
Entrez Gene	2047
Alt Symbol	ELK, EPHT2, Hek6, NET
Species	Human
Gene Type	protein-coding
Description	EPH receptor B1
Other Description	EK6|EPH-like kinase 6|eph tyrosine kinase 2|ephrin type-B receptor 1|neuronally-expressed EPH-related tyrosine kinase|soluble EPHB1 variant 1|tyrosine-protein kinase receptor EPH-2
Swissprots	O95143 Q0VG87 O43569 P54762 B3KTB2 A8K593 B5A969 O95142
Accessions	CAT16944 CCF76954 EAW79127 EAW79128 EAW79129 P54762 AF037333 AAB94627 AF037334 AAB94628 AK095305 BAG53024 AK291208 BAF83897 AK309741 AW207121 BC111744 AAI11745 BM665724 DA107464 EU826607 ACF47643 L40636 AAB08520 XM_011512540 XP_011510842 XM_011512541 XP_011510843 XM_011512542 XP_011510844 NM_004441 NP_004432
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formatio
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18034775}; Single-pass type I membrane protein {ECO:0000269|PubMed:18034775}. Early endosome membrane {ECO:0000269|PubMed:18034775}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity	Preferentially expressed in brain.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse Eph receptor B1 protein fragment - ab56257 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Mouse

Human Eph receptor B1 protein fragment - ab158374 from Abcam Category Protein Source Wheat germ Species Human

Human Eph receptor B1 protein fragment - ab185828 from Abcam Category Protein Source Mammalian Species Human

EPHB1 / EPH Receptor B1 Antibody Blocking Peptide - LS-E9113 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EphB1 Protein - H00002047-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EphB1 Recombinant Protein - P4682 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

EphB1 Peptide - P2632 from Novus Biologicals Category Peptide Species Human

EphB1-Antibody-C-term-Blocking-Peptide - BP7622a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human Cek 6 protein - orb138783 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human EphB1 protein - orb180258 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source Human Cells Species Human

EPHB1 - H00002047-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EPHB1 - H00002047-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EPHB1 - P4682 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

EPHB1 - P5708 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

EPHB1 Control Peptide - AP09998CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

EPHB1 fusion protein - Ag16347 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

EPHB1 fusion protein - ag18075 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human EPH Receptor B1, GST-His - EPHB1-746H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human EPHB1, His tagged - EPHB1-967H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human EPHB1, His & GST tagged - EPHB1-8550H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human EPHB1, GST-tagged - EPHB1-12492H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human EPHB1 - EPHB1-481H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human EPH Receptor B1, GST-tagged - EPHB1-1213H from Creative Biomart Category Protein Source Insect cells Species Human

EphB1 Protein, active, 10 µg - 14-674 from EMD Millipore Category Protein Prices $311.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

EPHB1/2 (pY594/604) Blocking Peptide - CBP3479 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken

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