| Gene Symbol |
LZTS2
|
| Entrez Gene |
84445
|
| Alt Symbol |
LAPSER1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine zipper, putative tumor suppressor 2
|
| Other Description |
hLZTS2|leucine zipper putative tumor suppressor 2|protein LAPSER1
|
| Swissprots |
Q8N3I0 D3DR72 Q96JL2 Q96J79 B1AL14 Q9BRK4
|
| Accessions |
EAW49790 EAW49791 EAW49792 Q9BRK4 AB058716 BAB47442 AK097997 AK298208 BAG60478 AL834338 CAD39005 AY029201 AAK31577 BC005855 AAH05855 BC006212 AAH06212 BC058938 AAH58938 BM544815 CB243010 XM_005270222 XP_005270279 XM_005270223 XP_005270280 XM_005270224 XP_005270281 XM_006718032 XP_006718095 NM_032429 NP_115805
|
| Function |
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
|
| Tissue Specificity |
Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. {ECO:0000269|PubMed:11709705}.
|